Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2005-06-14
2005-06-14
Mertz, Prema (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S300000, C530S317000, C530S351000, C514S002600, C424S085200
Reexamination Certificate
active
06906170
ABSTRACT:
Synthetic anti-inflammatory peptides derived from the sequence of IL-2 are provided. Parent peptides of the sequences Ile-Val-Leu, Glu-Phe-Leu-Asn-Arg-Trp-Ile-Thr (SEQ ID NO:1) and Arg-Met-Leu-Thr (SEQ ID NO:2), were obtained by elastase enzymatic digestion of IL-2, synthesized and modified. The peptides are useful in conditions of acute and chronic inflammation such as in autoimmune diseases.
REFERENCES:
patent: WO 95 00538 (1995-01-01), None
Fehali et al. Frontiers in Bioscience, vol. 2, pp. d12-d26, 1997.
Ariel, A. et al., “IL-2 Induces T Cell Adherence to Extracellular Matrix: Inhibition of Adherence and Migration by IL-2 Peptides Generated by Leukocyte Elastase,” J. Immunol. (1998), 161-5, 2465-2472.
Suzuki, K. et al., “Localization of Chemotactic Activity and 64 kD Protein Phosphorylation of Human Polymorphonuclear Leukocytes in N-terminus of the Chemotactic Protein LUCT/IL-8,” Biochem. Biophys. Res. Commun. (1989), 163(3), 1298-305.
Database WPI, Section Ch, Week 199136, Derwent Publications Ltd. London, GB. AN 1991-262316, XP002133615 & JP 03 170498 A (Teikoku Hormone MFG Co, Ltd.) Jul. 24, 1991.
Yavin et al, “Synthetic peptides derived from the sequence of human C-reactive protein inhibit the enzymatic activities of human leukocyte elastase and human leukocyte cathepsin G”,Int J Peptide Protein Res48:465-476 (1996).
Ariel Amiram
Fridkin Matityahu
Hershkoviz Rami
Lider Ofer
Yavin Eran J.
Browdy and Neimark PLLC
Hamud Fozia
Mertz Prema
Yeda Research and Development Co. Ltd.
LandOfFree
Anti-inflammatory peptides derived from IL-2 and analogues... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-inflammatory peptides derived from IL-2 and analogues..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory peptides derived from IL-2 and analogues... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3463401