Anti-inflammatory peptides derived from C-reactive protein

Details Anti-inflammatory peptides derived from C-reactive protein Anti-inflammatory peptides derived from C-reactive protein

2007-02-27

2007-02-27

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

C435S212000, C435S218000, C435S219000, C514S002600, C514S015800, C530S300000, C530S326000, C530S328000

Reexamination Certificate

active

10373794

ABSTRACT:
A peptide corresponding to positions 62–71 of the sequence of human C-reactive protein (CRP) of the formula: Glu62-Ile-Leu-Ile-Phe-Trp-Ser-Lys-Asp-Ile71and modifications thereof obtained by substitution, deletion, or addition of amino acids, amidation of the C-terminal or acylation of the N-terminal, are capable of inhibiting in vitro the enzymatic activity of human Leukocyte Elastase (hLE) and/or of human Cathepsin G (hCG) and can be used for the treatment of chronic inflammation conditions such as rheumatoid arthritis, pulmonary emphysema, cystic fibrosis, bronchitis, asthma and some acute respiratory distress syndrome.

REFERENCES:
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Yavin et al, “Synthetic peptides derived from the sequence of human C-reactive protein inhibit the enzymatic activities of human leukocyte elastase and human leukocyte cathespin G”,Int J Pept Protein Res48(5):465-76 (1996).
Yavin EA, “Binding pockets on the surface of human leukocyte elastase and human leukocyte cathepsin G. Implications to the design of inhibitors derived from human C-reactive protein”,Biomed Pept Proteins Nucleic Acids2(3):71-8 (1996-97).
Yavin EA, “Inhibition of the HLE and Cathespin G by Extended Peptides and Subunits Derived from Human C-reactive Protein”,Letters n Pept Sci4(3):157-166 (1997).
Yavin et al, “Peptides derived from human C-reactive protein inhibit the enzymatic activities of human leukocyte elastase and cathepsin G: use of overlapping peptide sequences to identify a unique inhibitor”,J Pept Res51(4):282-289 (1998).

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