Anti-inflammatory peptides

Details Anti-inflammatory peptides Anti-inflammatory peptides

2006-11-08

2010-11-16

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S331000

Reexamination Certificate

active

07833986

ABSTRACT:
Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula:X1-X2-X3wherein X1is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptanoic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine; X2is an acidic amino acid; and X3is an aliphatic amino acid; or of a peptide of the formula: X4-X5wherein X4is an aromatic or aliphatic amino acid; and X5is an acidic amino acid.

REFERENCES:
patent: 4012367 (1977-03-01), Mazur
patent: 4880779 (1989-11-01), Gallaher
patent: 5635593 (1997-06-01), Cheronis et al.
patent: 5837686 (1998-11-01), Kirby et al.
patent: 6117840 (2000-09-01), Arrhenius et al.
patent: 6586403 (2003-07-01), Mathison et al.
patent: 6852697 (2005-02-01), Mathison et al.
patent: 9806742 (1998-02-01), None
patent: 0063233 (2000-10-01), None
Mathison, R. et al., Regulation of Neutrophil Function by SMR1 C-Terminal Peptides (2000), Shock, v. 13 (Suppl.): 52 (Abstract 206).
J.M. Lee, et al. J. Neuropathol. Exp. Neurol. (2002) 61(2), pp. 125-131.
Befus, D. et al., Cervical Sympathetic Nerve Trunk-Submandibular Gland Axis: Neural Control of Anti-inflammatory Peptides that Modulate Airways Inflammation (2000), Canadian Network for Neuroimmune Biology Symposium, Winnipeg, Manitoba, Jun. 9-12, 2000.
Befus, D. et al., C-terminal Peptides of the Prohormone SMR1 Inhibit Allergic Information in the Airways (2000), CSI 2000, Quebec, Canada.
Befus, D. et al., Inhibition of Allergic Inflammation C-terminal Peptides of SMR1 (2000), CIA, Japan.
Davison, J.S. et al., Salivary Gland Peptides: Their role in Anaphylaxis and LPS-induced Inflammation, (2000), CANIB Symposium, Manitoba, Jun. 9-12, 2000.
Déry, R. et al., A Novel Peptide Isolated from Prohormone Smr1 Inhibits Allergic Inflammation of the Airways (2000), American Thoracic Society, Toronto, Canada, May 5-10, 2000.
Déry, R. et al., Inhibition of Airway Inflammation by feG: A C-Terminal Peptide Isolated from Rat Submandibular Gland Prohormone Smr1 (1999), Alberta Respiratory Disease Symposium, Banff, Alberta, Oct. 22-24, 1999.
Hwang, S. et al., Inhibition of Gene Expression in Human Cells Through Small Molecule-RNA Interactions (1999), PNAS, v. 96, pp. 12997-13002.
Llinas—Brunet et al., (1999), J.Med.Chem., v.42, pp. 722-729.
Mathison R: The Submandibular Glands: a role in homeostasis and allostasis. (1995), Biomedical Reviews, v. 4, pp. 61-69.
Mathison RD. et al., . Reduction in cardiovascular anaphylaxis by submandibular gland peptide-T (1995), Proc. West. Pharmacol. Soc., v. 40, pp. 73-74.
Mathison, R. et al., A Novel Submandibular Gland Peptide Protects Against Endotoxic and Anaphylactic Shock (1997), Am. J. Physiol., v. 273: R1017-R1023.
Mathison, R. et al., Attenuation of Intestinal and Cardiovascular Anaphylaxis by the Salivary Gland Tripeptide FEG and Its D-Isomeric Analog feG (1998), Peptides, v. 19, pp. 1037-1042.
Mathison, R. et al., Inhibition of Leucocyte Rolling by Submandibular Gland Peptide-T (CGP-T),(1999) Proc. West. Pharmacol. Soc., v. 42, pp. 39-40.
Mathison, R. et al., Neuroendocrine Regulation of Inflammation and Tissue Repair by Submandibular Gland Factors (1994), Immunology Today, v. 15, p. 527.
Mathison, R. et al., Reduction of endotoxin-induced leukocyte activation in the rat intestine by a D-isomeric analogue of salivary gland tripeptide FEG. (2000), Abstract: American Gastroenterology Association, San Diego, California, May 21-24, 2000.
Mathison, R. et al., Removal of the Submandibular Glands Increases the Acute Hypotensive Response to Endotoxin (1993), Circ. Shock, v. 39, p. 52.
Mathison, R. et al., Submandibular Gland Peptide-T (SGP-T) : Modulation of Endotoxic and Anaphylactic Shock, (1997), Drug Devel. Res., v. 42, pp. 164-171.
Mathison, R. et al., Submandibular Gland Peptide-T (SGP-T) Inhibits Intestinal Anaphylaxis (1997), Dig. Dis. Sci., v. 42, pp. 2378-2383.
Mathison, R. et al., The D-isomeric Analog of Salivary Gland Tripeptide FEG Reduces Endotoxin Induced Cell Activation in the Rat Intestine (1999), Falk Symposium: Neurogastroenterology—From the Basics to the Clinics, Jun. 21-22, 1999.
Mathison, R. et al., The Role of Submandibular Gland Peptide feG in Anaphylaxis-Induced Cardiac Inflammation (2000), Shock, v. 13 (Suppl.): 52.
Munch, G. et al., Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library (1999), Nature Biotech., v. 17, pp. 1006-1010.
Nkemdirim M. et al., Modulation of neutrophil activity by submandibular gland peptide-T (SGP-T). (1998), Pol. J. Pharmacol. v. 50: 417-424.
Ramaswamy K. et al., Marked Antiinflammatory Effects of Decentralization of the Superior Cervical Ganglia (1990), J. Exp. Med., v. 172, pp. 1819-1830.
Schullek, J. R. et al., A High-Density Screening Format for Encoded Combinatorial Libraries: Assay Miniaturization and Its Application to Enzymatic Reactions (1997), Anal. Biochem., v. 246, pp. 20-29.
Slootstra, Structural aspects of antibody-antigen interaction revealed through small random peptide libraries (1996), Molecular Diversity, v. 1, pp. 87-96.
Turesin, F. et al., The Role of Submandibular Gland Peptide feG in Anaphylaxis-Induced Cardiac Inflammation (2000), Shock, v. 13 (Suppl.): 52.
Dery, R.E., et al., Inhibition of Allergic Inflammation by C-Terminal Peptides of the Prohormone Submandibular Rat 1 (SMR-1), (2001), Int. Arch. Allergy Immunol., v. 124, pp. 201-204.
Grossmann, C. et al., Partitioning of Low Molecular Combination Peptides in Aqueous Two-Phase Systems of Poly(ethylene glycol) and Dextran in the Presence of Small Amounts of K2HPO4/KH2PO4Buffer at 293: experimental results, (1998), Biotechnology and Bioengineering, v. 60, no. 6, pp. 699-711.
Liakopoulou-Kyriakides, M. et al., Effect of Leu-(ASP, ASN, GLU, GLN) Dipeptides on Platelet Aggregation in vitro (1990), Biochemistry International, v. 22, No. 4, pp. 617-625.
Mathison, R. et al., Attenuation of Intestinal and Cardiovascular Anaphylaxis by the Salivary Gland Tripeptide FEG and its D-isomeric Analog feG, (1998), Peptides, v. 19, no. 6, pp. 1037-1042.
Metwally, E. et al., Submandibular Gland Tripeptide FEG (Phe-Glu-Gly) and Analogues: keys to structure Determination, (2002), Peptides, v. 23, pp. 193-199.
Schon, I. et al., Pentagastrin Analogs Containing α-aminooxy Acids, II, (1978), Hoppe-Seyler's Z. Physiol. Chem. Bd. 359, pp. 897-916.
Tan, D. et al., The Carboxamide feG(NH2) Inhibits Endotoxin Perturbation of Intestinal Motility, (2000), European Journal of Pharmacology v. 409, p. 203-205.
European Search Report for corresponding European Application No. EP 09002264.1, dated Aug. 12, 2009 (12 pages).
Ragusa et al. “Substrate Recognition and Selectivity of Peptide Deformylase. Similarities and Differences with Metzincins and Thermolysin”Journal of Molecular Biology 289(5):1445-1457 (1999).

Affiliated with

Also associated with

Rating

Anti-inflammatory peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-inflammatory peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4215685