Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-07-23
1996-01-02
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 15, 514 14, 530327, 530328, 530329, A61K 3800, C07K 500, C07K 700, C07K 1600
Patent
active
054808693
ABSTRACT:
Small, anti-inflammatory compounds that are peptide analogs are described useful to inhibit inflammation of a mammal's skin, mucous membranes, or lacerations of the musculature or injury to the brain or leakage of fluids into the air spaces of the lungs. Peptide analogs of the invention have the primary sequence T.sub.N -A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -A.sub.6 -T.sub.C where one of the moieties is in the D-configuration. A.sub.1 and A.sub.2 are each a basic polar amino acids while each of A.sub.3, A.sub.4, and A.sub.6 is a hydrophobic amino acid. A.sub.5 can be a variety of structures and appears to function to optimize the spatial relationship between the hydrophobic and the basic residues. T.sub.N is selected or modified to convey resistance against enzymatic degradation. T.sub.C is an amino group or an amidated amino acid, preferably hydrophobic.
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Thomas Holly A.
Wei Edward T.
Davenport A. M.
The Regents of the University of California
Warden Jill
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