Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1989-09-19
1991-09-03
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424613, 424617, 423598, A61F 1300, A61K 3340, A61K 3326
Patent
active
050453181
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to an anti-inflammatory oxidizing agent, the procedure for its production and various applications.
The production of disinfectants from titanium salts and hydrogen peroxide is known in the art. Refer, for instance, to Belgian patent No. 791 503 describing how a hydroxy gel is first produced from titanium salt solutions and hydrogen peroxide, after which further hydrogen peroxide is added at a pH value of 7. The disinfectant effect of such solutions is substantially the same as that obtained with hydrogen peroxide solutions.
According to the invention it has now proved possible to considerably improve the effect of such agents, while at the same time obtaining a substantially transparent agent.
This is achieved according to the invention substantially in that the active constituent of the proposed agent comprises the reaction product of H.sub.2 O.sub.2 and metallic titanium, said reaction product being in the form of a gel including a titanium peroxy radical and titanium peroxide, together with titanium hydroxide as important components in its structure.
Although the agent according to the invention has a wide range of anti-inflammatory applications, and various applications will also be described, the invention will be described in the following with reference to a specific area of application without, however, being limitied thereto.
It is well known that titanium is particularly suited for implantation in living tissue. One such application has been developed by Professor Branemark in Gothenburg and relates to the implantation of titanium screws into the jaw bone, the implanted titanium screws then serving as anchorage points for artificial teeth. Properties such as surface energy, dielectric constant, corrosion resistance, pK.sub.a and degree of hydration, of the oxide layer on the titanium surface of these screws have been considered important for osseo-integration although their significance has not been conclusively proven. However, it has been proven that the phenomena appearing during the period immediately after implantation are of the utmost importance in establishing biointegration. During this period the inevitable inflammatory reaction caused by the surgical trauma must heal suitably. The initial inflammatory reaction to the implant is characterised by the presence of cells which neutralize and degrade foreign objects. These cells (polymorphonuclear leukocytes and macrophages) are characterised by their ability to produce tissue-degrading enzymes, free oxygen radicals and H.sub.2 O.sub.2 and engulf foreign particles. Clinical experiments have shown that some of the oxygen radicals produced are extremely dangerous to living tissue; they may attack metals and participate in the production of biologically active mediators.
The object of the agent according to the invention is to achieve wide-spread inhibition of these conditions around such implant bodies, thus considerably shortening the healing period required.
Another object of the invention is to provide a multipurpose anti-inflammatory agent and an oxidizing agent, particularly a biocompatible oxidizing agent, as well as an agent suitable for cell cultivation, and an agent for treating other inflammatory conditions, such as arthritis.
When using the agent according to the invention for, any kind of implant, the gel is spread on the implant after manufacture and the implant is then stored in the gel until the moment of use. The implant is then cleaned and disinfected and its gel coating inhibits acute inflammation which inevitably occurs when tissue is incised. The implant bodies should of course be kept in suitable containers to avoid degradation due to reduction of the gel.
The gel-like product according to the invention offers optimal properties thanks to its double-oxidizing effect, i.e. by means of both the radical and H.sub.2 O.sub.2.
The gel proposed according to the invention decomposes in two stages as follows: redox-potential as H.sub.2 O.sub.2.
The agent according to the invention can also be used to
REFERENCES:
Advanced Inorganic Chemistry, Cotton and Wilkinson, p. 699, 1980.
Bjursten Lars-Magnus
Lundstrom Ingemar
Tengvall Pentti
Kishore G. S.
Page Thurman K.
The Institute for Applied Biotechnology
LandOfFree
Anti-inflammatory oxidizing agent, the procedure for its product does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-inflammatory oxidizing agent, the procedure for its product, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory oxidizing agent, the procedure for its product will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1007876