Anti-inflammatory nitro and thia-fatty acids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C554S111000, C562S553000, C562S571000

Reexamination Certificate

active

06924309

ABSTRACT:
The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)min which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH2)j(COOH)kin which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.

REFERENCES:
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patent: 3578687 (1971-05-01), Larkin et al.
patent: 587992 (1947-06-01), None
Kobayashi, T., “The reaction of nitrogen dioxide with lung surface components: the reaction of cis-9-octadecenoic acid” Chemosphere, vol. 12(9-10), pp. 1317-1325 (1983). [CAS Online Abstract].
Doering et al, “Toxicity of myristic acid analogs toward African typanosomes” Proc. Natl. Acad. Sci. vol. 91, pp. 9735-9739 (Oct. 1994).
Gupta et al, “Nitration of .beta. and .gamma. acetoxy olefinic fatty acids” Journal of the Oil Technologists' Association of India, vol. 18(2), pp. 46-49 (1986). (as abstracted by CAPLUS).
D'lschia et al, “Medium-dependent Competitive Pathways in the Reactions of Polyunsaturated Fatty Acids with Nitric Oxide in the Presence of Oxygen . . . ” Tetrahedron, vol. 55, pp 9297-9307 (Jul., 1999).
Lima et al, “Characterization of Linoleic Acid Nitration in Human Blood Plasma by Mass Spectrometry” Biochemistry, vol. 41, pp. 10717-10722 (2002).

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