Anti-inflammatory indole derivatives

Details Anti-inflammatory indole derivatives Anti-inflammatory indole derivatives

2005-06-28

2005-06-28

Desai, Rita (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S492000

Reexamination Certificate

active

06911465

ABSTRACT:
Therapeutic compounds of formula (I) wherein X is CH2or SO2; R1is an optionally substituted aryl or heteroaryl ring; R2and R3are various specified groups, R4is a group NHCOR15, NHSO2R15or OCONR16R17where R15, R16and R17are various defined groups; and R5, R6and R7are independently selected from hydrogen, a functional group or an optionally substituted hydrocarbyl groups or optionally substituted heterocyclic groups; and further provided that when R4is a group NHCOR15, R15is substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; as well as pharmaceutical compositions containing them are described and claimed. These compounds and compositions are useful in the treatment of disease mediated by MCP-1 (monocyte chemoattractant protein-1) or RANTES (Regulated Upon Activation, Normal T-cell Expressed and Secreted), such as inflammatory disease.

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