Anti-inflammatory furanone compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514444, 514460, 514473, 549 58, 549313, 549315, 549370, A61K 3138, C07D33354, C07D30732

Patent

active

051128535

ABSTRACT:
New furanone compounds have anti-inflammatory, immunosuppresive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis. A compound of the invention is 4-[3,6-dihydro-6-hydroxy-5-(3-phenylpropyl)-2H-pyran-2-yl]-5-hydroxy-2-(5H )-furanone.

REFERENCES:
patent: 2359096 (1944-09-01), Elderfield
patent: 2359208 (1944-09-01), Elderfield
patent: 4447445 (1984-05-01), Jacobs
patent: 4786651 (1988-11-01), Wheeler
patent: 4789749 (1988-12-01), Jacobs et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
patent: 4874782 (1989-10-01), Bonjouklian et al.
patent: 4916241 (1990-04-01), Hayward et al.
patent: 4935530 (1990-06-01), Lee
patent: 5013850 (1991-05-01), Lee
patent: 5037811 (1991-08-01), Lee
patent: 5043457 (1991-08-01), Lee
patent: 5045564 (1991-09-01), Lee
Bonjuklian, et al., Chemical Abstracts, vol. 106, 15620c, p. 670 (1987).
Reynolds et al, J. Am. Chem. Soc., 110, pp. 5172-5177 (1988).
Tocanne et al., Chemical Abstracts 69 76581k, p. 7146 (1968).
Deems, et al, Biochimica et Biophysica Acta, 917 pp. 258-268 (1987).
Scheuer et al., Journal of the American Chemical Society 100:1 p. 307 (Jan. 4, 1978).
Graziano, et al., Chemical Abstracts 107, (1987), 236559t.
Roll et al., Org. Chem. 1988, 53 3276-8.
Negishi et al., J. Org. Chem 45, pp. 5223-5225, (1980).
E. D. de Silva et al., "Tetrahedron Letters", 21:1611-1614 (1980).
Nakagawa et al., "Aldose reductase inhibitor from Palaun sponges" Chem. Abstract 106: 96126b.
Tanaka, et al., The Chemical Society of Japan, Chemistry Letters, pp. 633-636 (1983).
Tanis, et al., Tetrahedron Letters, vol. 25, No. 40, pp. 4451-4454 (1984)--Furans in Synthesis 4. Silyl Furans as Butenolide Equivalents.
Graziano, et al, "Photosensitized Oxidation of Furans", Part 12, Solvent Effects In Thermal Rearrangement Of The 2,5-Peroxides Of 2,5-Unsubstituted Furans, J. Chem, Soc., Perkin Trans, 1, (8), 1833-9, Apr. 19, 1989.
David Nettleton, et al, Inflammation Research Association, Fifth International Conference Poster Session, Phospholipase A.sub.2 Inhibition by Dihydrofuranones, Sep. 23-27, 1990.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-inflammatory furanone compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-inflammatory furanone compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory furanone compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2426223

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.