Anti-inflammatory factor, method of isolation, and use

Details Anti-inflammatory factor, method of isolation, and use Anti-inflammatory factor, method of isolation, and use

1997-07-22

1999-11-09

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Milk or colostrum

4242781, 514 54, 536 24, A61K 3520

Patent

active

059809531

ABSTRACT:
The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.

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Goldman, A.S. et al., "Anti-inflammatory Properties of Human Milk," Acta. Poediatr. Scand. 75:689-695 (1986).
Owens, W.E. and Nickerson, S.C., "Evaluation of an Anti-Inflammatory Factor Derived from Hyperimmunized Cows," Proc. Soc. Exp. Biol. Med. 190(1):79-86 (1989).
Derwent WPI Acc. No. 78-29814A/197816, English Language Abstract for Japanese Patent Publication No. 53-26312, published Mar. 11, 1978 (Doc. A01).
Ormrod, D.J. et al., "A low molecular weight component derived from the milk of hyperimmunised cows suppresses inflammation by inhibiting neutrophil emigration," Agents Actions 37:70-79 (1992).
Ormrod, D. J. et al., "Milk from hyperimmunized dairy cows as a source of a novel biological response modifier, " Agents Actions 38, Spec. Conf. Issue:C146-C149 (1993).

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