Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami

Details Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami

Filed on

1984-12-20

Date issued

1986-02-04

Examiner

Jiles, Henry R.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514448, 514438, 514469, 514471, 549 57, 549 64, 549 65, 549467, 549487, A61K 3134, A61K 3138, C07D30746, C07D30780

Type

Patent

Status

active

Patent number

045686912

Description

ABSTRACT:
The invention concerns novel esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl)phenols of the formula: ##STR1## and salts thereof, wherein R.sup.1 and R.sup.2 are (3-5C)alkyl, R.sup.3 and R.sup.4 are hydrogen or methyl, A is a direct bond or methylene, and Q is various heteroaromatic containing groups. The esters possess topical anti-inflammatory properties and the invention provides pharmaceutical compositions containing the esters and processes for their chemical manufacture.

REFERENCES:
patent: 3686206 (1972-08-01), Posselt et al.
patent: 4303649 (1981-12-01), Jones
patent: 4323575 (1982-04-01), Jones
patent: 4355045 (1982-10-01), Preston et al.
Jones et al., CA, vol. 89, 1978, 89:129233V, p. 564.

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