Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami

Details Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)-alkylami

1984-12-20

1986-02-04

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514448, 514438, 514469, 514471, 549 57, 549 64, 549 65, 549467, 549487, A61K 3134, A61K 3138, C07D30746, C07D30780

Patent

active

045686912

ABSTRACT:
The invention concerns novel esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl)phenols of the formula: ##STR1## and salts thereof, wherein R.sup.1 and R.sup.2 are (3-5C)alkyl, R.sup.3 and R.sup.4 are hydrogen or methyl, A is a direct bond or methylene, and Q is various heteroaromatic containing groups. The esters possess topical anti-inflammatory properties and the invention provides pharmaceutical compositions containing the esters and processes for their chemical manufacture.

REFERENCES:
patent: 3686206 (1972-08-01), Posselt et al.
patent: 4303649 (1981-12-01), Jones
patent: 4323575 (1982-04-01), Jones
patent: 4355045 (1982-10-01), Preston et al.
Jones et al., CA, vol. 89, 1978, 89:129233V, p. 564.

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