Anti-inflammatory deoxyribosides

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 24, 536 26, 536 27, 536 28, A61K 3170, C07H 1700, C07H 1512

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active

044811977

ABSTRACT:
The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed reaction of the appropriately substituted 3-deazapurine with a 2'-deoxyribose donor.

REFERENCES:
patent: 4056674 (1977-11-01), Robins et al.
patent: 4210639 (1980-07-01), Chiang et al.
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4322411 (1982-03-01), Vinegar et al.
Chem. Abstracts 95:81396v, (1981).
Chem. Abstracts 96:91647n, (1982).
Chem. Abstracts 96:120885w, (1982).

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