Anti-inflammatory compounds for ophthalmic use

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

552553, 552554, C07J 900

Patent

active

054461774

ABSTRACT:
Anti-inflammatory compounds, a method of treating inflamed ocular tissue and compositions of these compounds are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.

REFERENCES:
patent: 3007923 (1961-11-01), Muller et al.
patent: 4447445 (1984-10-01), Philibert et al.
patent: 4472392 (1984-09-01), Anderson et al.
patent: 4472393 (1984-09-01), Shapiro
patent: 4524134 (1985-06-01), Kominek et al.
patent: 4588530 (1986-05-01), Lee
patent: 4617299 (1986-10-01), Knepper
patent: 4686214 (1987-08-01), Boltralik
patent: 4762919 (1988-08-01), Lee
Chemical Abstracts, vol. 13, No. 15, abstract No. 132583d, Oct. 8, 1990.
Cairns, et al., "The 21-alkylation of 20-Oxopregnanes and Synthesis of a Novel Anti-Inflammatory 16.alpha., 17.alpha., 21-Trimethyl Steroid," J. of the Chemical Society, Aug., 1981, pp. 2306-2316.
Mitsukuchi et al., "Studies on Topical Antiinflammatory Agents. IV. 21-(Alkylthio)Acetates and (Methylthio) methoxides of Corticosteroids." Chem. Pharm. Bull. 38(3) 786-789 (1990).
Allen, W. S. et al., "The Synthesis of 21-0-Alkylhydrocortisone Derivatives and of 11.beta.-Hydroxy-17-.alpha., 21-methylenedioxy-4-pregnene-30,20-dione." J. Org. Chem., 26:4153-4155 (1961).
Boltralik et al., Invest. Ophthal., 13 (Supp.):78 (1974).
Bradlow, H. L. et al., "Isolation and Identification of Four New Carboxylic Acid Metabolites of Cortisol in Man." JCE&M, 37(5):811-818 (1973).
DiPetrillo et al., "Anti-Inflammatory Adrenal Steroids That Neither Inhibit Skin Collagen Synthesis nor Cause Dermal Atrophy." Arch. Dermatol., 120:878-883 (1984).
Dunne et al., "Double-blind Clinical Trial of Topical Steroids in Anterior Uveitis." Br. J. Ophthal., 63:762-767 (1979).
Eilon et al., "Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effects on intraocular pressure." Br. J. Ophthal., 65:644-647 (1981).
Heiman et al., "Stabilization of Rat Liver Lysosomes by New Anti-Inflammatory Steroids in vitro." Steroids, 38(4):365-373 (1981).
Hirschmann et al., "An Approach to an Improved Antiinflammatory Steroid. The Synthesis of 11.beta.,27-Dihydroxy-3,20-dione-1,4-pregnadien-21-vl--Acetamid 2-deoxy-.alpha.-D-glucopyranoside." JACS, 86:3903-3904 (1964).
Knepper, Esq. Eye Res., 27:567 (1978).
Lee et al., "Antiinflammatory Activity of Two Novel Derivatives of Prednisolone." Res. Com. Chem. Path. Pharmacol., 27(3):611-614 (1980).
Lee et al., "Anti-Inflammatory Steroids Without Pituitary-Adrenal Supression." Science, 215:989-991 (1982).
Lloyd-Jones et al., "Clinical evaluation of clobetasone butyrate eye drops in episcleritis." Br. J. Ophthal., 65:641-643 (1981).
Phillips et al., The Lancet, 767-768 (Apr. 7, 1984).
Phillips et al., "Eye Drops of RU 486-6, A Peripheral Steroid Blocker, Lower Intraocular Pressure in Rabbits." The Lancet, vol. 1, No. 8380 (1984).
Ramsell et al., "Clinical Evaluation of Clobetasone Butyrate: a comparative study of its effects in postoperative inflammation and on intraocular pressure." Br. J. Opnthal., 64:43-45 (1980).
Rousseau et al., "17.beta.-Carboxamide Steroids are a New Class of Glucocorticoid Antagonists." Nature, vol. 279 (1979).
Soliman et al., "Local Antiinflammatory Activity of Acid Ester Derivatives of Prednisolone." Res. Com. Chem. Path. Pharmacol., 33(2):357-360 (1981).
Southren et al., Invest. Ophthal. Vis. Sci., 26:393 (1985).
Southren et al., "Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite: 3.beta., 5.beta.-Tetrahydrocortisol." Investigative Ophthalmology & Visual Science, 28:902-903 (1987).
Velluz, L. et al., "Principe d'acces aux 18-nor-corticosteroids-L.alpha.18-nor-cortisone." Compt. Rend. 250:371-373 (1960).
Williamson et al., "Clobetasone Butyrate Eye Drops: Effect on Ocular Inflammation and Intraocular Pressure." Trans. Ophthal. Soc. U.K., 101:27-29 (1981).
Zorbach et al., "21-Methoxyprogesterone Improved Synthesis." J. Org. Chem., 22:1127 (1957).
Physicians Desk Reference, 15th Ed., pp. 82-83 (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-inflammatory compounds for ophthalmic use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-inflammatory compounds for ophthalmic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory compounds for ophthalmic use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1820403

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.