Anti-inflammatory compounds for ophthalmic use

Details Anti-inflammatory compounds for ophthalmic use Anti-inflammatory compounds for ophthalmic use

1992-03-17

1993-06-29

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514912, A61K 3156

Patent

active

052234932

ABSTRACT:
Anti-inflammatory compounds, a method of treating inflamed ocular tissue and compositions of these compounds are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.

REFERENCES:
patent: 4588530 (1986-05-01), Lee
patent: 4617299 (1986-10-01), Knepper
Philips, et al., The Lancet, 767-768 (Apr. 7, 1984).
Knepper, Esp. Eye Res., 27:567 (1978).
Southren, et al., Invest. Ophthal. Vis. Sci., 26:393 (1985).
Southren et al., Invest. Ophthal. Vis. Sci., 28:901 (1987).
Boltralik et al., Invest. Ophthal., 13 (Supp.):78 (1974).

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