Anti-inflammatory compounds for ophthalmic use

Details Anti-inflammatory compounds for ophthalmic use Anti-inflammatory compounds for ophthalmic use

1985-10-30

1987-08-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514180, 514181, 514914, A61K 3156

Patent

active

046862145

ABSTRACT:
Anti-inflammatory compounds and a method of treating inflamed ocular tissue utilizing these compounds are described. The steroidal actives are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.

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patent: 4472393 (1984-09-01), Shapiro
patent: 4477445 (1984-10-01), Philibert et al.
Phillips et al, "Eye Drops of RU 486-6, A Peripheral Steroid Blocker, Lower Intraocular Pressure in Rabbits", The Lancet, vol. 1, No 8380 (1984).
Rousseau, et al, "17.beta.-Carboxamide Steroids are a New Class of Glucocorticoid Antagonists", Nature, vol. 279 (1979).
Chemical Abstracts; vol. 96 (1982); #35625s; Cairns et al.

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