Anti-inflammatory compounds derived from Pseudopterogorgia...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C514S033000, C514S680000, C514S681000, C514S691000, C536S018100, C552S296000, C585S021000, C585S026000

Reexamination Certificate

active

07060686

ABSTRACT:
Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formulawherein R1is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5is hydrogen, CH3, or CH2OH, and R6is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.

REFERENCES:
patent: 4447445 (1984-05-01), Jacobs et al.
patent: 4745104 (1988-05-01), Jacobs et al.
patent: 4849410 (1989-07-01), Jacobs et al.
patent: 5624911 (1997-04-01), Fenical et al.
Rodriguez et al., J. Nat. Prod., vol. 64, pp. 100-102, 2001, published on web Nov. 17, 2000.
Look, SA, et al. (1986) “The Pseudopterosins: Anti-Inflammatory and Analgesic Natural Products from the Sea WhipPseudopterogorgia elisabethae” PNAS USA 83:6238-6240.
Look, SA, et al. (1986) “The Pseudopterosins: A New Class of Antiinflammatory and Analgesic Diterpene Pentosides from the Marine Sea WhipPseudopterogorgia elisabethae(Octocorallia)” J. Org. Chem. 51:5140-5145.
Look, SA, and W. Fenical (1987) “The Seco-Pseudopterosins, New Anti-Inflammatory Diterpene-Glycosides from a Caribbean Gorgonian Octocoral of the GenusPseudopterogorgia” Tetrahedron 43(15):3363-3370.
Roussis, V, et al. (1990) “New Antiinflammatory Pseudopterosins from the Marine OctocoralPseudopterogorgia elisabethae” J. Org. Chem. 55:4916-4922.

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