Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-22
2005-02-22
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000
Reexamination Certificate
active
06858579
ABSTRACT:
According to the present invention, there is provided a compound comprising the amino acid sequence AMVSE, wherein said compound does not comprise the amino acid sequence EQEYVQTV. Preferably the compound contains 5-11 amino acids. The compound is used in the manufacture of a medicament or pharmaceutical composition for inhibiting leukocyte migration, or treating or preventing inflammation and/or inflammatory response/disease from such conditions as gout, gouty arthritis, rheumatoid arthritis, asthma, reperfusion injury or damage, stroke, myocardial infarction, septic shock, or a skin disorder.
REFERENCES:
patent: 4950646 (1990-08-01), Wallner et al.
Seemann et al. 1996; Molecular Biology of the Cell 7:1359-1374.*
L.H. Lim et al., Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: Effect of lipocortin1, Proceedings of the National Academy of Sciences of the United States of America, 1998, 95(24), 14535-9.
J.D. Croxtall et al., N-Terminal Peptide fragments of Lipocortin-1Inhibit A549 Cell Growth and Block EGF-Induced Stmulation of Proliferation, International Journal of Cancer, 1993, 54(1), 153-8.
M. Perretti et al., Lipocortin-1 Fragments Inhibit Neutrophil Accumulation and Neutrophil-Dependent Edema in the Mouse, Journal of Immunology, 1993, 151(8), 4306-14.
Croxtall et al., Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: identification of E-Q-E-Y-V as a crucial component, British Journal of Pharmacology, 1998, 123, 975-983.
Oxford Dictionary of Biochemistry and Molecular Biology, Oxford University Press 1997, pp. 537-538.
I.T. Paulsen et al., Characterisation ofsin, a potential recombinase-encoding gene fromStaphylococcus aureus, Gene, 1994, 141, 109-114.
P. Dezelee et al., Small Deletion inv-srcSH3 Domain of a Transformation Defective Mutant of Rous Sarcoma Virus Restores Wild Type Transforming Properties, Virology, 1992, 189, 556-567.
Flower Roderick
Perritti Mauro
Carlson Karen Cochrane
Mathews, Collins Shepherd & McKay, P.A.
William Harvey Research Limited
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