Anti-inflammatory compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S032000, C544S034000

Reexamination Certificate

active

07807668

ABSTRACT:
Compounds of formula (I) or formula (II) have anti-inflammatory activity and comprise a new class of NSAIDs. The compounds are useful for treating inflammatory diseases or disorders. The invention also provides pharmaceutical compositions containing these compounds, as well as methods of treating inflammatory diseases or disorders using compounds of formula (III) or formula (IV).

REFERENCES:
patent: 3040041 (1962-06-01), Schellhammer
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Banker, G.S. et al, “Modern Pharmaceutices, 3ed.” Marcel Dekker, New York, 1996, pp. 451 and 596.
STN File CA, abstract 138:351250; & A. Aiello, et al; European Journal of Organic Chemistry (2003), 5, 898-900. See abstract and CAS Registry Nos. 519154-45-1 and 519154-46-2.
STN File CA, abstract 54:2182; & C.W. Schellhammer and S. Petersen, Ann. (1959), 624, 108-119. See abstract and CAS Registry No. 121761-11-3.
Aiello, A., et al; “Conicaquinones A and B, Two Novel Cytotoxic Terpene Quinones from the Mediterranean AscidianAplidium conicum”; Eur. J. Org. Chem.; pp. 898-900 (2003).
Townsend, N.O., et al; “Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione, the B,C,D ring core of the shermilamine alkaloids”;Org. Biomol. Chem.; pp. 3557-3563 (2003).
Schmitz, F.J., et al; “Xesto- and Halenaquinone Derivatives from a Sponge,Adociasp., from Truk Lagoon1”;J. Org. Chem.; 53, pp. 3922-3925 (1988).
Schellhammer, C.W., et al; Uber Derivate Des Chinolinchinons-(5.8);Ann.; 624, pp. 108-119 (1959).
Pearce, A. N., et al; “Anti-inflammatory Thiazine Alkaloids Isolated from the New Zealand AscidianAplidiumsp.: Inhibitors of the Neutrophil Respiratory Burst in a Model of Gouty Arthritis”;American Chemical Society and American Society of Pharmcognosy; 5 pgs. (2006).

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