Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-06
2007-03-06
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S326000, C514S256000, C544S333000, C544S335000, C546S210000
Reexamination Certificate
active
10746034
ABSTRACT:
The present invention provides compositions and their use in the treatment of inflammatory diseases caused by T-cell proliferation such as sepsis, inflammatory bowel diseases, autoimmune encephalomyelitis, or lupus. The compositions comprise disubstituted ureas of Formulas I, II, III or IV:in-line-formulae description="In-line Formulae" end="lead"?R1—NH—CO—NH-Q-R2Formula I:in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?Et-NH—CO—NH-Q-R2: Formula (II)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?Et-NH—CO—NH—(CH2)3—NR6R7: Formula (III)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?Me2N—(CH2)3—NH—CO—NH-Q-R2. Formula (IV)in-line-formulae description="In-line Formulae" end="tail"?
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Miller Robert J.
Nahill Sharon R.
Staveski Mark M.
Blundell Isabelle A. S.
Genzyme Corporation
Seaman D. Margaret
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