Anti-inflammatory compositions and methods

Details Anti-inflammatory compositions and methods Anti-inflammatory compositions and methods

1994-09-30

1998-10-06

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

530351, A61K 4505

Patent

active

058173056

ABSTRACT:
Therapeutic compositions and methods for the treatment of inflammation are disclosed. The compositions comprise at least one anti-inflammatory drug in combination with the lymphokine interleukin-4 (IL-4), which components interact synergistically in the treatmement of inflammation. Methods for the treatment of inflammation comprise administering to a subject in need of such treatment an effective amount of at least one anti-inflammatory drug and IL-4.

REFERENCES:
patent: 4985241 (1991-01-01), Zimmerman et al.
Abbas, Am. J. Pathol., vol. 129(1), pp. 26-33, 1987.
Oppenheim et al. (editors), "Immunophysiology", Oxford Univ. Press, pp. 96-98, 1990.
Hamblin, "Lymphokines", IRL Press, pp. 26-28, 1989.
Stites et al., (editors), "Basic & Clin. Immunology", 7th Edition, Appleton & Lange, pp. 90-91, 1991.
Jones et al., "Bailliere's Clin. Haematology", vol. 2(1), Chap. 6, 1989.
Hart, et al. Proc. Natl. Acad. Sci. 86 3803-3807 (1989) "Potential Anti-inflammatory Effect of IL-4".
Schleimer, et al. J. Immunol. 143 (4) 1310-1317 (1989) "Regulation of Human Basophil Mediator . . . ".
Hart et al. Lymphokine Research 9 (2) 147-153 (1990) "Augmentation of Glucocorticoid Actions on Human . . . ".

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