Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-09-06
2005-09-06
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C548S535000, C562S445000
Reexamination Certificate
active
06939855
ABSTRACT:
The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting compounds for use in such compositions and methods.
REFERENCES:
patent: 4018913 (1977-04-01), Okamoto et al.
patent: 4018915 (1977-04-01), Okamoto et al.
patent: 4036955 (1977-07-01), Okamoto et al.
patent: 4041156 (1977-08-01), Okamoto et al.
patent: 4046876 (1977-09-01), Okamoto et al.
patent: 4055636 (1977-10-01), Okamoto et al.
patent: 4055651 (1977-10-01), Okamoto et al.
patent: 4069318 (1978-01-01), Okamoto et al.
patent: 4070457 (1978-01-01), Okamoto et al.
patent: 4071621 (1978-01-01), Okamoto et al.
patent: 4073914 (1978-02-01), Kikumoto et al.
patent: 4096255 (1978-06-01), Kikumoto et al.
patent: 4097591 (1978-06-01), Okamoto et al.
patent: 4104392 (1978-08-01), Okamoto et al.
patent: 4260601 (1981-04-01), Reichelt
patent: 4804676 (1989-02-01), Inaoka et al.
patent: 4910190 (1990-03-01), Bergeson et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 4981873 (1991-01-01), Witte et al.
patent: 4992421 (1991-02-01), De
patent: 5338755 (1994-08-01), Wagnon et al.
patent: 5362902 (1994-11-01), Barnish et al.
patent: 5397801 (1995-03-01), Wagnon et al.
patent: 5481005 (1996-01-01), Wagnon et al.
patent: 5578633 (1996-11-01), Wagnon et al.
patent: 5650428 (1997-07-01), Ohmori et al.
patent: 5688913 (1997-11-01), Arrhenius et al.
patent: 6001809 (1999-12-01), Thorsett et al.
patent: 6093696 (2000-07-01), Head et al.
patent: 6110945 (2000-08-01), Head et al.
patent: 6197794 (2001-03-01), Head et al.
patent: 6221888 (2001-04-01), Durette et al.
patent: 6229011 (2001-05-01), Chen et al.
patent: 6239108 (2001-05-01), Lin et al.
patent: 6248713 (2001-06-01), Lin et al.
patent: 6265572 (2001-07-01), Chen et al.
patent: 6274577 (2001-08-01), Brown et al.
patent: 6288267 (2001-09-01), Hull et al.
patent: 6306840 (2001-10-01), Adams et al.
patent: 6329362 (2001-12-01), Achribald et al.
patent: 6329372 (2001-12-01), Head et al.
patent: 6348463 (2002-02-01), Head et al.
patent: 6362204 (2002-03-01), Head et al.
patent: 6369229 (2002-04-01), Head et al.
patent: 6376538 (2002-04-01), Adams et al.
patent: 6380387 (2002-04-01), Sidduri et al.
patent: 6388084 (2002-05-01), Kaplan et al.
patent: 6403608 (2002-06-01), Langham et al.
patent: 6407066 (2002-06-01), Dressen et al.
patent: 6420600 (2002-07-01), Sidduri et al.
patent: 6423688 (2002-07-01), Thorsett et al.
patent: 6423728 (2002-07-01), Hull et al.
patent: 6426348 (2002-07-01), Hull et al.
patent: 6436904 (2002-08-01), Ashwell et al.
patent: 6455539 (2002-09-01), Langham et al.
patent: 6455550 (2002-09-01), Chen et al.
patent: 6458844 (2002-10-01), Hull et al.
patent: 6147073 (1975-04-01), None
patent: 23 57 334 (1974-06-01), None
patent: 26 55 636 (1977-06-01), None
patent: 0 526 348 (1993-02-01), None
patent: 9711143.9 (1997-05-01), None
patent: 9714314.3 (1997-07-01), None
patent: 9714316.8 (1997-07-01), None
patent: 9714335.8 (1997-07-01), None
patent: 9722674.0 (1997-10-01), None
patent: 9800680.2 (1998-01-01), None
patent: 9800684.4 (1998-01-01), None
patent: 9800686.9 (1998-01-01), None
patent: 04 154732 (1992-05-01), None
patent: 06 016625 (1994-01-01), None
patent: 08 073422 (1996-03-01), None
patent: 92/16549 (1992-10-01), None
patent: 94/07815 (1994-04-01), None
patent: 94/12181 (1994-06-01), None
patent: 95/15973 (1995-06-01), None
patent: 96/01644 (1996-01-01), None
patent: 96/20725 (1996-07-01), None
patent: 96/20949 (1996-07-01), None
patent: 96/22966 (1996-08-01), None
patent: 97/03094 (1997-01-01), None
patent: 97/48726 (1997-12-01), None
patent: 98/04247 (1998-02-01), None
patent: 98/42656 (1998-10-01), None
patent: 98/53814 (1998-12-01), None
patent: 98/53817 (1998-12-01), None
patent: 98/53818 (1998-12-01), None
patent: 98/54207 (1998-12-01), None
patent: 98/58902 (1998-12-01), None
patent: 99/06432 (1999-02-01), None
patent: 99/06436 (1999-02-01), None
patent: 99/10312 (1999-03-01), None
patent: 99/10313 (1999-03-01), None
patent: 99/67230 (1999-12-01), None
Theien, B. E. (Journal of Clinical Investigation 107 (8) 995-1006, 2001).
Smith (J Biol Chem 271, 28485, 1996).
Palmer (J Cell Biol 123, 1289, 1993).
Yokosaki, Yasuyuki (J. Biol Chem 269(43), 26691-96, 1994).
U.S. Appl. No. 60/086,241 USA filed Mar. 21, 1997.
U.S. Appl. No. 60/022,890 USA filed Jul. 25, 1996.
U.S. Appl. No. 60/032,786 USA filed Dec. 6, 1996.
U.S. Appl. No. 60/047,856 USA filed May 29, 1997.
U.S. Appl. No. 60/047,954 USA filed May 29, 1997.
U.S. Appl. No. 60/048,017 USA filed May 29, 1997.
U.S. Appl. No. 60/066,525 USA filed Nov. 25, 1997.
U.S. Appl. No. 60/066,787 USA filed Nov. 25, 1997.
U.S. Appl. No. 60/066,831 USA filed Nov. 25, 1997.
U.S. Appl. No. 08/821,825 USA filed Mar. 21, 1997.
Archibald, S.C., et al., “Discovery and Evaluation of Potent, Tyrosine-Based α4β1 Integrin Antagonists”,Bioorg&Med. Chem. Lett., vol. 10, pp. 997-999 (2000).
Crossley, M.J., et al. “Studies on the Effects of Pharmacological Agents on Antigen-Induced Arthritis in BALB/c Mice.”Drugs Exptl. Clin. Res. XIII(5): 273-277 (1987).
Dutta, A.S., et al. “Potent Cyclic Monomeric and Dimeric Peptide Inhibitors of VLA-4 (α4β1 Integrin)-Mediated Cell Adhesion Based on the Ile-Leu-Asp-Val Tetrapeptide.”J. Peptide Sci. 6: 321-341 (2000).
El-Naggar, A.M., et al.,Acta. Pharm. Jugosl. (1985), 35(1), 15-22.
Engleman, V.W., et al. “Cell Adhesion Integrins as Pharmaceutical Targets.”Ann. Reports in Med. Chem. 31: 191-200 (1996).
Ewenson, A. et al., “Analogues of Substance P Containing an α-hydroxy, β-amino acid: Synthesis and Biological Activity”,Eur. J. Med. Chem., vol. 26, pp. 435-442 (1991).
Fotouhi, N., et al., “The Design and Synthesis of Potent Cyclic Peptide VCAM-VLA-4 Antagonists Incorporating an Achiral Asp-Pro Mimetic”,Bioorg.&Med. Chem. Lett., vol. 10, pp. 1171-1173 (2000).
Haubner, R., et al. “Cyclic RGD Peptides Containing β-Turn Mimetics.”J. Am. Chem. Soc.118: 7881-7891 (1996).
Hauptmann, J., et al. “Degradation of a Benzamidine-Type Synthetic Inhibitor of Coagulation Enzymes in Plasma of Various Species.”Thrombosis Research. 61: 279-284 (1991).
Haworth, D., et al. “Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion.”Br. J. Pharmacol. 126: 1751-1760 (1999).
Jackson, D.Y., et al., “Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents”,J. Med. Chem., vol. 40, pp. 3359-3368 (1997).
Kato, Y., et al., “Oxidative Degradation of Collagen and Its Model Peptide by Ultraviolet Irradiation”,J. Agric. Food Chem., vol. 40, pp. 373-379 (1992).
Komoriya, A., et al. “The Minimal Essential Sequence for a Major Cell Type-specific Adhesion Site (CS1) within the Alternatively Spliced Type III Connecting Segment Domain of Fibronectin Is Leucine-Aspartic Acid-Valine.”J. Biol. Chem. 266(23): 15075-15079 (1991).
Kudlacz, E., et al., “Pulmonary Eospinophilia in a Murine Model of Allergic Inflammation is Attenuated by Small Molecule α4β1 Antagonists”,J. of Pharm and Exp. Ther., vol. 301, No. 2, pp. 747-752.
Kurokawa, M., et al. “Synthesis and Antiinflammatory Activity of cis- and trans-6,6a,7,8,9,10,10a,11-Octahydro-11-oxodibenzo[b,e]thiepinacetic and -oxepinacetic Acids.”J. Med. Chem. 33: 504-509 (1990).
Leibfritz, D., et al.,Tetrahedron(1982), 38(14), 2165-81.
Lin, K., et al., “Selective, Tight-Binding Inhibitors of Integrin α4β1 that Inhibit Allergic Airway Responses”,J. Med. Chem., vol. 42, pp. 920-934.
Müller, G., et al., “Discovery and Evaluation of Piperidinyl Carboxylic Acid Derivatives as Potent α4β1Integrin Antagonists”,Bioorg.&Med. Chem. Lett., ol. 11, pp. 3019-3021 (2001).
Papaioannou, D., et al
Pleiss Michael A.
Yednock Theodore A.
Elan Pharmaceuticals Inc.
Foley & Lardner LLP
Lukton David
Weber Jon
Wyeth
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