Anti-inflammatory composition and method with des-Tyr dynorphin

Details Anti-inflammatory composition and method with des-Tyr dynorphin Anti-inflammatory composition and method with des-Tyr dynorphin

1993-06-09

1996-01-09

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530326, 530329, A61K 3800, C07K 700, C07K 706, C07K 708

Patent

active

054829305

ABSTRACT:
A method for treating inflammatory conditions is provided in which a peptide is administered in an amount effective to decrease inflammation, with the peptide having the sequence

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Fan, et al, Brain Research, vol. 623 (1), 1993.
U.S. Ser. No. 07/925081, filed Aug. 4, 1992, Wei et al.
Long et al., "Hindlimb Paralytic Effects of Prodynorphin-Derived Peptides Following Spinal Subarachnoid Injection in Rats," European Journal of Pharmacology, 153 (1988), pp. 45-54.
Takemori et al., "Suppression by Dynorphin A and [Des-Tyr.sup.1 ]Dynorphin A Peptide of the Expression of Opiate Withdrawal and Tolerance in Morphine-Dependent Mice," J. of Pharmacol. & Exper. Therap., 266(1), (1993), pp. 121-124.
Goldstein et al., "Nonopiate Effects of Dynorphin and Des-Tyr-Dynorphin," Science, 218 (10 Dec. 1982), pp. 1136-1138.
Wei et al., "Anti-Inflammatory Peptide Angonist," Annu. Rev. Pharmacol. Toxicol., 33 (1993), pp. 91-108.
Wei et al., "Corticotropin-Releasing Factor Inhibits Neurogenic Plasma Extravasation in the Rate Paw," J. of Pharmacol. & Exper. Therap., 238(3), pp. 783-787 (1986).
Wei et al., "Peptides of the Corticoliberin Superfamily Attenuate Thermal and Neurogenic Inflammation in Rat Pawskin," European Journal of Pharmacology, 168 (1989), pp. 81-86.

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