Anti-inflammatory CD14 peptides

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241981, 4242781, 514 2, 514 9, 514 12, 514 16, 530300, 530317, 530324, 530328, A61K 3800, C07K 14705

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active

057665931

ABSTRACT:
The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.

REFERENCES:
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Juan et al. (1995) The Journal of Biological Chemistry 270: 1382-1387.
Pugin et al. (1994) Immunity 1:509-516.
Setoguchi et al. (1989) Biochimica et Biophysica Acta. 1008:213-222.
Viriyakosol et al. (1995) The Journal of Biological Chemistry 270:331-368.
Juan et al. (1995), `Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64`, J. Bio Chem 270(10):5219-5224.
Juan et al. (1995), `Identification of a domain in sCD14 essential for Lipopolysaccharide (LPS)signaling but not LPS binding`, J Bio Chem 270(29):17237-17242.
McGinley et al. (1950, `CD14: Physical properties and identification of an exposed site that is protected by Lipopolysaccharide`, J Bio Chem 270(10):5213-5218.
Weinstein (1983), `Chemistry and Biochemistry of Amino Acids, Peptides and Proteins`, Marcel Dekker, Inc. 7:336-345.

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