Anti-inflammatory benzoic acid derivatives

Details Anti-inflammatory benzoic acid derivatives Anti-inflammatory benzoic acid derivatives

1995-02-16

1996-06-25

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562491, 562432, 562473, 562441, 562454, 562468, 562474, C07C 6336, C07C 6500

Patent

active

055301576

ABSTRACT:
Novel benzoic acid derivatives have the formula: ##STR1## wherein --X-- represents C.sub.1 to C.sub.6 alkylene, C.sub.2 to C.sub.6 alkenylene or a divalent moiety having the structure --(CH.sub.2).sub.m --Z-- in which m is an integer from 0 to 3 and Z represents --O--, --S-- or --NH--;

REFERENCES:
Garratt et al., "Wittig Reactions of 1,2-Dihydro-1,2-bis(triphenylphosphoranylidene)-benzocyclobutene-1,2-quino ne. The Synthesis of Dibenzo[a,c]benzo[3,4]cyclobuta[1,2-f]cyclo-octane" J. Chem. Soc. (1970) 2137-2141.
Nogradi, M., "The Synthesis of Some Dibenzo[a,d]-cycloheptenes, Tribenzo[a,c,e]cycloheptenes and Heterocyclic Analogues, Model Compounds for Conformational Studies" Acta Chimica Academiae Scientarum Hungaricae (1978) 96:393-404.
Burch et al., "N-(Fluorenyl-9-methoxycarbonyl)amino acids, a class of antiinflammatory agents with a different mechanism of action" Proc. Natl. Acad. Sci. USA (1991) 88:335-359.

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