Anti-inflammatory and anti-HIV compositions and methods of use

Details Anti-inflammatory and anti-HIV compositions and methods of use Anti-inflammatory and anti-HIV compositions and methods of use

2008-05-29

2010-12-21

Leith, Patricia (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Containing or obtained from hypericum

Reexamination Certificate

active

07854946

ABSTRACT:
The metabolic fingerprint and anti-inflammatory activity and anti-HIV activity ofH. gentianoidesis disclosed. High performance liquid chromatography (HPLC) analysis shows thatH. gentianoidescontains a family of compounds, including some not previously observed in otherHypericumspecies.H. gentianoidesextracts and fractions from these extracts reduce prostaglandin E2 synthesis in mammalian macrophages and inhibit HIV in infected HeLa cells. The present invention provides extracts and fractions thereof fromH. gentianoidesfor use in pharmaceutical compositions and methods for the treatment or inhibition of inflammation, prostaglandin E-mediated disease, disorder or condition, a cyclooxygenase-mediated disease, disorder or condition, or an HIV infection.

REFERENCES:
Recio et al. Screening of Tropical Medicinal Plants for Antiinflammatory Activity. Phytotherapy Research, vol. 9, pp. 571-574 (1995).
Rocha et al. Antibacterial Phloroglucinols and Flavonoids From Hypericum Brasiliense. Phytochemistry. vol. 40. No. 5, pp. 1446-1452. 1995.
Ishiguro et al. Saroaspidin A, B, and C: Additional Antibiotic Compounds from Hypericum Japonicum. Planta Medica. 1987. pp. 415-417.
Roche et al. More Phloroglucinols from Hypericum Brasiliense. Phytochemistry. vol. 42. Issue 1. May 1996. Abstract. 3 pages.
Hillwig, Matthew L., et al., “Better Understanding Bioactivity in Hypericum Species Through Metabolomics” Abstract and Poster from the Metabolics Society Third Annual Conference, Boston, MA, Jun. 25-28, 2006, 2 pages.

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