Anti-inflammatory and anti-arthritic pyrazolo-[1,5-a]-1,3,5-tria

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514246, 544211, 544212, 544219, 544220, A61K 3138, A61K 3144, A61K 3153, C07D25172

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active

047344148

ABSTRACT:
The invention features compounds having anti-arthritic activity and having the formula ##STR1## wherein X is an alkyl group having between 1 and 8, inclusive, carbon atoms and Y is a hydroxyalkylamino group having between 2 and 8, inclusive, carbon atoms; a dialkylamino group having between 2 and 12, inclusive, carbon atoms; a carboxyalkylamino group having between 2 and 9, inclusive, carbon atoms; a heterocycloalkyl group having between 2 and 5, inclusive, carbon atoms and having nitrogen as a hetero atom; an alkylthioalkylamino group having between 3 and 10, inclusive, carbon atoms; or a heteroarylalkylthioalkylamino group having between 5 and 14, inclusive, carbon atoms and having ntrogen as a hetero atom.
The invention further features compounds having similar activity and having the formula ##STR2## wherein A is H, an alkyl group having between 1 and 8, inclusive, carbon atoms, an aralkyl group having between 6 and 14 inclusive, carbon atoms, an aryl group having between 5 and 14, inclusive, carbon atoms, or a heteroaryl grour having between 3 and 12, inclusive, carbon atoms and having nitrogen as a hetero atom; and B is H, benzyl, a carboalkoxy group having between 2 and 8, inclusive, carbon atoms, or an allyl group having between 3 and 8, inclusive, carbon atoms.
The invention additionally features compounds having similar activity and having the formula ##STR3## wherein r is an integer between 2 and 4, inclusive.

REFERENCES:
Capuano et al, Chem. Ber. 104, (1971) 3039-3047.
Senga et al, J. Med. Chem., 25 (1982) pp. 243-248.
Durant et al, J. Med. Chem., 20 (1977) pp. 901-907.
Kobe et al, J. Het., 11 (1974) pp. 199-204.
Capuno et al. (1974) Chem. Ber. 104:3039.
Kobe et al. (1974) J. Het. Chem. 11:199.
Senga et al. (1973) J. Het. Chem. 12:893.
Senga et al. (1982) J. Med. Chem. 25:243.
Durant et al. (1977) J. Med. Chem. 20:901.

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