Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-11-24
1979-04-03
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
2603405R, 260386, 260562P, 260607AR, 260609F, 260571, 424258, 424263, 424311, 424324, 424330, 424335, 424337, 424340, 424341, 546152, 546343, 568719, 568633, 568707, 560139, A61K 31045, A61K 31085, A61K 3109, A61K 31135
Patent
active
041478061
ABSTRACT:
The active constituents of these medicaments are compounds of the general formula: ##STR1## in which R represents a sulfur or oxygen atom or a >SO or >SO.sub.2 radical or even a ##STR2## IN WHICH R.sub.1 and R.sub.2 which can be the same or different, represent a hydrogen atom or a hydroxyl, aryl, alkyl, arylalkyl, alkylaryl possibly halogenated or a heterocyclic radical, said radicals being substituted or unsubstituted, while R' and R", which may be the same or different, represent a hydrogen atom, a metal such as an alkali or alkaline-earth metal or magnesium, or the ammonium ion or an alkyl radical, an aliphatic or aromatic acyl radical or a heterocyclic radical, which radicals may be substituted or unsubstituted. The process enables the products to be prepared in sufficiently pure form for therapeutic use. .beta.-naphthol is reacted with a suitable aldehyde in an acetic medium, in the presence of hydrochloric acid added dropwise at between 5.degree. and 10.degree. C. Purification is by recrystallization from benzene or a mixture of solvents containing benzene.
REFERENCES:
bennett et al.; C. A. vol. 73 (1970) p. 308.
Thompson et al.; C. A. vol. 41 (1947) pp. 3902-3912.
Laboratoires Creat
Robinson Allen J.
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