Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-03-11
1987-05-05
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514337, 514397, 514422, 546274, 548336, 548525, 549 52, 549 54, 549 55, 549 56, A61K 3138, A61K 31415, C07D33364, C07D40904
Patent
active
046633448
ABSTRACT:
3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of 2-(2-carboxy-phenylthio)-.alpha.-substituted acetic acids. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory diseases and other prostaglandin and/or leukotriene mediated diseases.
REFERENCES:
patent: 3954748 (1976-05-01), Thominet
patent: 4410539 (1983-10-01), Cross et al.
Durette Philippe L.
Gallagher Timothy F.
Rupprecht Kathleen M.
Tischler Allan N.
Witzel Bruce E.
Cheng Theresa Y.
Ford John M.
Merck & Co. , Inc.
Mullins J. G.
Sudol Michael C.
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