Anti-inflammatory/analgesic combination of cyclo-(N-methyl-Ala-T

Details Anti-inflammatory/analgesic combination of cyclo-(N-methyl-Ala-T Anti-inflammatory/analgesic combination of cyclo-(N-methyl-Ala-T

1983-06-27

1984-10-02

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

A61K 3700

Patent

active

044747667

ABSTRACT:
Combinations of cyclo-(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe) and a NSAID have been found to exhibit much lower gastric lesions or ulcers than normally associated with NSAIDs and are thereby clinically useful in long-term therapy for patients suffering from chronic rheumatoid arthritis or osteoarthritis.

REFERENCES:
patent: 4310518 (1982-01-01), Freidinger et al.
Chem. Abstr. vol. 98, 1983, 752v.
Chem. Abstr. vol. 94, 1981, 76964d.
Chem. Abstr. vol. 91, 1979, 117810j.
Chem. Abstr. vol. 87, 1977, 63200g.
Chem. Abstr. vol. 89, (1978), 53800e.
Chem. Abstr. vol. 98, (1983), 84216j.
Biol. Abstr. (1978), 64207, vol. 65.

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