Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-s

Details Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-s Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-s

1975-03-17

1976-12-21

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424304, 424317, A61K 31235, A61K 3119

Patent

active

039989666

ABSTRACT:
2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

REFERENCES:
patent: 1951686 (1934-03-01), Wolfram
patent: 3663584 (1972-05-01), Alvarez
patent: 3681432 (1972-08-01), Nelson
Elseivier's Encyclopedia of Org. Chem., Series III, vol. 12B, (1953), pp. 3276, 3310, 3311, 3325, 3326, 3338, 3412 & 3470.
Chemical Abstracts 62: 5238f (1965).
Chemical Abstracts 66: 1142521e, (1967).

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