Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2010-09-07
2011-12-13
Henley, III, Raymond (Department: 1629)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S315000, C514S424000
Reexamination Certificate
active
08076323
ABSTRACT:
The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder,but excluding (S)-3-(1′-methylcyclohexylcarbonylamino)-caprolactam: whereinz is 1, 2, 3 or 4;A is —CO— or —SO2—;Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alklylaminoalkyl, haloalkyl, aryl or substituted aryl;T1and T2together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7;and each hydrogen atom bonded to the carbon atoms in the ring generated by T1and T2may be independently be substituted by a group R1, where R1is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms;or each R1is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.
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Fox, David J., et al., “Identification of 3-(Acylamino)azepan-2-ones as as Stable Broad-Spectrum Chemokine Inhibitors Resistant to Metabolism in Vivo”, J. Med. Chem 48, (2005), pp. 867-874.
Fox David John
Grainger David J.
Bone Richard G. A.
Cambridge Enterprise Limited
Henley III Raymond
VLP Law Group LLP
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