Anti-inflammatory 1-phenylethanolamine derivatives pharmaceutica

Details Anti-inflammatory 1-phenylethanolamine derivatives pharmaceutica Anti-inflammatory 1-phenylethanolamine derivatives pharmaceutica

1978-08-03

1982-10-19

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050117, 26050118, 2604045, 424316, 424324, 564 47, 564 48, 564 56, 564 99, 564123, 564168, 564170, 564178, 564182, 564185, 564189, 564190, 564220, A01N 4728, A01N 3718

Patent

active

043550452

ABSTRACT:
The invention relates to topically anti-inflammatory 1-phenylethanolamine derivatives of the general formula I: ##STR1## or acid-addition salts thereof, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. A representative compound is 1-(4-amino-3,5-dichlorophenyl)-2-[1,1-dimethyl-2-(2-phenylacetamido)ethyla mino]ethanol. The derivatives are useful in particular for the treatment of inflammatory diseases or conditions of the skin.

REFERENCES:
patent: 3536712 (1970-10-01), Keck et al.
patent: 3944611 (1976-03-01), Smith
patent: 3975443 (1976-08-01), Harper et al.
Burger, "Medicinal Chemistry", 3rd Ed., Part II, pp. 953-954, (1970).

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