Anti-infective and lubricious medical articles and method for th

Details Anti-infective and lubricious medical articles and method for th Anti-infective and lubricious medical articles and method for th

1989-01-18

1990-05-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 427 2, 523112, 523113, 523122, 604265, 604317, A61L 3300

Patent

active

049256688

ABSTRACT:
A substantially hydrophilic polymeric medical article has a coating of chlorhexidine and a silicone on its surface and may have chlorhexidine bulk distributed throughout the polymer. The invention includes a method for preparing the article which includes dipping the article into a solution of chlorhexidine and silicone in a solvent. The method may also include preparing a melt of a substantially hydrophilic polymer having bulk distributed chlorhexidine by twin screw compounding a mixture of polymer and chlorhexidine and extruding the melt into the shape of the desired article prior to applying the coating.

REFERENCES:
patent: 4117035 (1978-09-01), Hillier et al.
patent: 4186745 (1980-02-01), Lewis et al.
patent: 4460369 (1984-07-01), Seymour
patent: 4604412 (1986-08-01), Joh et al.
patent: 4675347 (1987-06-01), Mochizuki et al.
patent: 4806621 (1989-02-01), Kohn et al.

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