Anti-infective and antithrombogenic medical articles and method

Details Anti-infective and antithrombogenic medical articles and method Anti-infective and antithrombogenic medical articles and method

1992-11-24

1995-09-19

Rosenbaum, C. Fred

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

604265, 523112, 523122, 424 7808, 427 225, 427 23, A01N 102, A61M 2500

Patent

active

054514240

ABSTRACT:
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.

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