Anti-infective and antithrombogenic medical articles and method

Details Anti-infective and antithrombogenic medical articles and method Anti-infective and antithrombogenic medical articles and method

1990-03-21

1991-05-07

Lee, Lester L.

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

523112, 523122, 424 78, A61M 2500, A61M 100, A61K 3174, A61L 2900

Patent

active

050133063

ABSTRACT:
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.

REFERENCES:
patent: 4581028 (1986-04-01), Fox
patent: 4678660 (1987-07-01), McGary et al.
patent: 4713402 (1987-12-01), Solomon

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