Anti-infective and antithrombogenic medical articles and method

Details Anti-infective and antithrombogenic medical articles and method Anti-infective and antithrombogenic medical articles and method

1989-12-07

1991-03-12

Brown, Johnnie R.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

424 78, 424 83, 514822, 523122, 523112, 604266, 524916, 524195, A01N 102, A61L 2900, A61M 2500, A61K 3174

Patent

active

049992104

ABSTRACT:
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine, an antibiotic, or an antithrombogenic agent permeated into the surface or it may be a polymeric surface layer having bulk distributed chlorhexidine laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine. The article may then be laminated by dipping into a solution of chlorhexidine and a substantially hydrophilic polymer in a solvent.

REFERENCES:
patent: 4675347 (1987-06-01), Mochizuki et al.
Condensed Chem. Dictionary , p. 713, 10th Edition, G. G. Hawley, Van Nostrand Reinhold Co., 1981.

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