Anti-infective agents

Details Anti-infective agents Anti-infective agents

2007-07-13

2010-02-16

Habte, Kahsay T (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S222800

Reexamination Certificate

active

07662958

ABSTRACT:
The present invention provides HCV polymerase inhibiting compounds having the formula (I):where R1is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5is RaSO2N(Rj)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino])-4-hydroxy -2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.

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