Anti-infective agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S260100, C514S267000, C544S003000, C544S009000, C544S010000, C544S011000, C544S012000

Reexamination Certificate

active

07902203

ABSTRACT:
The present invention provides an HCV polymerase inhibiting compound having the formula (I)and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

REFERENCES:
patent: 3133918 (1964-05-01), MacPhillamy et al.
patent: 3291794 (1966-12-01), Huebner
patent: 3499082 (1970-03-01), De Stevens et al.
patent: 5378704 (1995-01-01), Weller
patent: 6348587 (2002-02-01), Schinazi et al.
patent: 7378414 (2008-05-01), Hutchinson et al.
patent: 2004/0087577 (2004-05-01), Pratt et al.
patent: 2004/0097492 (2004-05-01), Pratt et al.
patent: 2004/0162285 (2004-08-01), Pratt et al.
patent: 2005/0075331 (2005-04-01), Pratt et al.
patent: 2008/0193413 (2008-08-01), Hutchinson et al.
patent: 2008/0214528 (2008-09-01), Wagner et al.
patent: 386435 (1965-04-01), None
patent: 0 618 209 (1998-12-01), None
patent: 885950 (1962-02-01), None
patent: WO0132153 (2001-05-01), None
patent: WO0132153 (2001-05-01), None
patent: WO0160315 (2001-08-01), None
patent: WO0160315 (2001-08-01), None
patent: 01/85172 (2001-11-01), None
patent: WO0190121 (2001-11-01), None
patent: WO0190121 (2001-11-01), None
patent: WO0204425 (2002-01-01), None
patent: WO0204425 (2002-01-01), None
patent: 02/098424 (2002-12-01), None
patent: WO-0185172 (2002-12-01), None
patent: WO-02098424 (2002-12-01), None
patent: 03/037262 (2003-05-01), None
patent: 03/059356 (2003-07-01), None
patent: WO 03/059356 (2003-07-01), None
patent: WO-03059356 (2003-07-01), None
patent: WO2004041818 (2004-05-01), None
patent: WO-2004/058150 (2004-07-01), None
patent: WO2005019191 (2005-03-01), None
patent: WO2005019191 (2005-03-01), None
patent: WO2008011337 (2008-01-01), None
Dhanak et al, Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase, J. Biol. Chem., vol. 277, Issue 41, 38322-7, 2002.
Dhanak et al., “Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase,” Journal of Biological Chemistry 277(41); 38322-38327 (2002).
Dhanak et al., “Identification and Biological Characterization of Heterocyclic Inhibitors of the Heptitis C Virus RNA-Dependent RNA Polymerase,” 9thInternational Meeting on HCV and Related Viruses, Jul. 7-11, 2002; San Diego, CA; Abstract #0-3, p. 21.
McHutchison, The American Association for the Study of Liver Diseases, Hepatitis Single Topic Conference: Hepatitis C New Drug and Clinical Trials Development: Promises and Pitfalls. Abstract #5; Feb. 27-Mar. 1, 2003, Chicago, IL.
Ukrainets et al., “4-Hydroxy-2-Quinolones. 42*. Synthesis and biological Activity of 1-R-2-Oxo-3-(2H-1,2,4-Benzothiadiazine-1,1-Dioxid-3-Yl)-4-Hydroxyquinolines,” Chemistry of Heterocyclic Compounds 36(3):346-350 (2000).
M. Barbero et al.,Synthetic Application of Tris(methylthio)methyl Salts. An Efficient Route to Trithioorthocarboxylic Esters from Strongly Activated Aromatic and Heteroaromatic Systems, Synthesis pp. 22-25 (Jan. 1988).
K.J. Blight et al.,Efficient Initiation of HCV RNA Replication in Cell Culture, Science 290:1972-4 (2000).
D.R. Buckle et al.,4-Hydroxy-3-nitro-2-quinolones and Related Compounds as Inhibitors of Allergic Reactions, J. Med. Chem. 18(7):726-32 (1975).
I.D. Entwistle et al.,Rapid Catalytic Transfer Reduction of Aromatic Nitro Compounds to Hydroxylamines, Tetrahedron 34(2):213-5 (1978).
H. Eschenhof et al,A New Synthesis of 3-Deazathymidine and of a Related Phosphoramidite Synthon, Tetrahedron 48(30):6225-30 (1992).
F. Fabis et al.,Thiaisatoic Anhydrides: Efficient Synthesis under Microwave Heating Conditions and Study of their Reactivity, Tetrahedron 54(36):10789-800 (1998).
E. Fischer et al,Ueber Einige Neue Indazolderivate, Chem. Ber. 35: 2315-9 (1902).
Y. Girard et al.,A New Synthesis of 1,2,4-Benzothiadiazines and a Selective Preparation of o-Aminobenzenesulphonamides, J. Chem. Soc. Perkin I:1043-7 (1979).
A. Goldfarb,New Compounds. Derivatives of 2,5-Diaminobenzenesulfonamide, J. Amer. Chem. Soc. 65(4):738-9 (1943).
M. Ikeda et al.,Selectable Subgenomic and Genome-Length Dicistronic RNAs Derived from an Infectious Molecular Clone of the HCV-N Strain of Hepatitis C Virus Replicate Efficiently in cultured Huh7 Cells, J. Virol. 76(6):2997-3006 (2002).
S.N. Kovalenko et al.,Recyclization of 2-Imino-2H-1-Benzopyrans Under the Influence of Nucleophilic Reagents. 2. Reaction of 2-Iminocoumarin-3-carboxamindes with oAminobenzenesulfonamide, Chem. Het. Com. 34(7):791-5 (1998).
D.J. LeCount et al.,Synthesis of 3-Diethylamino-1-ethylisothiazolo[3,4-b]pyridinium Perchlorate and an Improved Route to 3-Azaisatoic Anhydride, Synthesis pp. 972-3 (1982).
D.C. Leysen et al.,Thiazolopyridine Analogs of Naldixic Acid 1. Thiazolo[5,4-b]pyridines, J. Het. Chem. 21:401-6 (1984).
J.F. Morrison et al.,Approaches to the Study and Analysis of the Inhibition of Enzymes by Slow- and Tight-Binding Inhibitors, Comm. Mol. Cell. Biophys. 2:347-68 (1985).
F.E. Nielsen et al.,6-Chloro-3-alkylamino-4h-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells, J. Med. Chem. 45(19):4171-87 (2002).
M. Rowley et al.,3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex, J. Med. Chem. 36(22):3386-96 (1993).
W. Stadlbauer et al.,Ring Closure and Rearrangement Reactions of 4-Azido-2-oxoquinoline-3-carboxylates and 4-Azidocoumarin-3-carboxylates [1], J. Het. Chem. 35:627-36 (1998).
P. Stanetty et al.,An Improved Synthetic Approach to Thieno[2,3-d]-1,2,3-thiadiazole-carboxylates via Diazotization of Aminothiophene Derivatives, J. Het. Chem 36:761-5 (1999).
J.G. Topliss et al.,Antihypertensive Agents. I Non-diuretic 2H-1 ,2,4-Benzothiadiazine 1,1-Dioxides, J. Med. Chem. 6(2):122-7 (1963).
B. Unterhalt et al.,2,3-Dihydro-3-oxo-thienoisothiazol-1,1-dioxide and ihre 3-Thioxo-Verbindungen, Pharmazie 6:115-7 (1994).
J.D. Warren et al.,Synthesis of substituted 2H-1,3-oxazine-2,6-diones by Reaction of Trimethylsilyl Azide with Maleic Anhydrides, J. Org. Chem. 40(6):743-6 (1975).
S.S. Washburne et al.,Ethyl Oxaorotate—A New Synthetic Route to 1,3-Oxazine-2,6-Diones, Tetrahedron Let. 4: 243-6 (1976).
M. Winn et al.,2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists, J. Med. Chem. 36(18):2676-88 (1993).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-infective agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-infective agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-infective agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2695671

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.