Anti-infarction molecules

Details Anti-infarction molecules Anti-infarction molecules

2003-02-05

2010-10-12

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07811992

ABSTRACT:
Disclosed are compositions and methods for treating ischemia and molecules related to hibernation states. FPA molecules having the sequence set forth in SEQ ID NO: 2 can be used for as anti-infarction agents.

REFERENCES:
patent: 4187217 (1980-02-01), Chipens et al.
patent: 5648331 (1997-07-01), Koudsi et al.
patent: 5767269 (1998-06-01), Hirsh et al.
patent: 6294519 (2001-09-01), Oeltgen et al.
patent: 6815425 (2004-11-01), Meyerhoff et al.
patent: WO 99/56766 (1999-11-01), None
patent: WO 99/56767 (1999-11-01), None
Channabasavaiah, K., et al. “Fibrinopeptides. IV. Synthesis of human fibrinopeptide A.” Int. J. Pept. Pro. Res. 1976, 8(3), 323-9.
Scherer R., et al. “The effect of fibrinopeptides A and B on experimental allergic encephalomyelitis.” Clin. Exp. Immunol. 1980, 40, 49-59.
Miller, B.A., et al. “Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion.” Neurophys. Bas. Clin. 2001, 12(8), 1663-9.
Smith, P. “Oral anticoagulants are effective long term after acute myocardial infarction.” J. Int. Med. 1999, 245, 383-387.
Ginalski et al. “Practical lessons from protein structure prediction.” Nuc. Ac. Res., 2005, 33, 1874-1891.
Rudinger “Characteristic of the amino acids as components of a peptide hormone sequence.” (Peptide Hormones (Ed. J.A. Parson). University Park Press. Baltimore, 1976, pp. 1-7.
Pitt et al. “Single amino acid substitution mutants of Klebsiella pneumoniae singma54 defective in transcription” Nuc. Ac. Res., 2000, 28, 4419-4427.
Bradley et al. “Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Subsitutions in Each Repeat” J. Mol. Biol., 2002, 324, 373-386.
Flanagan et al. “Truncated staphyloccal nuclease is compact but disordered” Proc. Natl. Acad. Sci. USA, 1992, 89, 748-752.
Sawai et al. “Impact of single-residue mutations on the structure and function of ovispirin
ovispirin antimicrobial peptides” Prot. Engin., 2002, 15, 225-232.
Schnog et al. “Sickle cell disease; a general overview” J. Med., 2004, 62, 364-374.
Becker “Anticoagulation and the Heart,” J. Thrombosis and Thrombolysis, 2001, 12, 41-52.
Aarts et al. Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor-PSD-95 Protein Interactions.Science298:846-850 (2002).
Andrews et al. Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal.PNAS95:8392-8397 (1998).
Ayaka et al. Molecular Mapping of Thrombin-Receptor Interactions.Proteins: Structure, Function and Genetics45:107-116 (2001).
Bitting et al. C-fos MRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation.Neurosci Lett, 165:117-21 (1994).
Bolli R .The late phase of preconditioning.Circ Res87(11):972-83 (2000).
Bolling et al. Hibernation triggers and myocardial protection.Circulation98(19 Suppl):II220-3; discussion II223-4 (Nov. 10, 1998).
Bolling et al. Use of “natural” hibernation induction triggers for myocardial protection.Ann Thorac Surg64(3):623-7 (Sep. 1997).
Bruce et al. Circannual variations in bear plasma albumin and its opiod-like effects on guinea pig ileum.Pharmacol Biochem Behav53:885-9 (1996).
Bruce et al. Is the Polar Bear (Ursus maritimus) a Hibernator?: Continued Studies on Opioids and Hibernation.Pharmacol Biochem Behav35:705-711 (1990).
Bruce et al. Suppression of guinea pig ileum induced contractility by plasma albumin of hibernators.Pharmacol Biochem BehavSep;43(1):199-203 (1992).
Cantwell and Di Cera, Rational Design of a Potent Anticoagulant Thrombin.J. of Biol. Chem. 275(51):39827-39830 (Dec. 2000).
Chen et al. The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-s and reduction of TUNEL-positive cells. J Cereb Blood Flow Metaqb 21:34-40 (2001).
Chien et al. Extension of tissue survival time in multiorgan block preparation with a delta opioid DADLE ([D-Ala2, D-Leu5]-enkephalin)J Thorac Cardiovasc SurgMar;107(3):964-7 (1994).
Chien et al. Two-day preservation of major organs with autoperfusion multiorgan preparation and hibernation induction trigger.J. Thorac Cardiovascular Surg102:224-34 (1991).
Cooper HA and Braunwald E., Clinical importance of stunned and hibernating myocardium.Coron Artery Dis12:387-92 (2001).
Cote et al. Hemostatic markers in patients at risk of cerebral ischemia.Stroke31(8):1856-62 (Aug. 2000).
Cui et al. In vivo microdialysis study on changes in septal dynorphin and beta-endorphin activities in active and hibernating Columbian ground squirrels.Brain Res710:271-1 (1996).
Dawson et al. Cerebrovascular hemodynamics and ischemic tolerance: lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion.J Cereb Blood Flow Metab6:616-23 (1999).
Di Cera et al. The Na+ Binding Site of Thrombin.J. Of Biol. Chem.270(38):22089-22092 (Sep. 1995).
Diener et al. Lubeluzole in Acute Ischemic Stroke Treatment A Double-Blind study with an 8-Hour Inclusion Window Comparing a 10-mg Daily Dos of Lubeluzole with Placebo.Stroke2543-2551 (Nov. 2000).
Fallavollita et al. Stability f Hibernating Myocardium in Pigs with a Chronic Left Anterior Descending Coronary Artery Stenosis: Absence of Progressive Fibrosis in the Setting of Stable Reductions in Flow, Function and Coronary Flow Reserve.J. of the Amer. College of Cardiology37(7):1989-1995 (Jun. 2001).
Fassbender et al. Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator.Stroke30(10):2101-4 (Oct. 1999).
Ford et al. Angiotensin II reduces infarct size and has no effect on post-ischemic contractile dysfunction in isolated rat heartsBr. J. Pharmacol.134(1):38-45 (2001).
Ford et al. Characterization of cardioprotection mediated by AT2 receptor antagonism after ischemia-reperfusion in isolated working rat heartsJ. Cardiovasc. Pharmacol. Ther. 5(3):211-21 (2000).
Ford et al. Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat heartsCirculation94(12):3087-9 (1996).
Frerichs et al. Local cerebral blood flow during hibernation, a model of natural tolerance to “cerebral ischemia”.J Cereb Blood Flow Metab14:193-205 (1994).
Furuya et al. Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia.J Cereb Blood Flow Metab3:226-32 (2001).
Furuya et al. Examination of Several Potential Mechanisms for the Negative Outcome in a Clinical Stroke Trial of Enlimomab, a Murine Anti-Human Intercellular Adhesion Molecule-1 Antibody: A Bedside-to-Bench Study.Stroke32(11):2665-74 (Nov. 2001).
Futterman LG and Lemberg L., Hibernating myocardium, stunning, ischemic preconditioning: clinical relevance.Am J Crit Care9:430-6 (2000).
Ginis et al. TNF-alpha pretreatment prevents subsequent activation of cultured brain cells with TNF-alpha and hypoxia via ceramide.Am J Physiol, 276:C1171-83 (1999).
Gorham et al. Hibernation induces expression of moesin in intestinal epithelial cells.Cryobiology37:146-54 (1998).
Grotta J; The Combination Therapy Stroke Trial Investigators. Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole.Cerebrovasc Dis12:258-63 (2001).
Hashimi et al. Loss of myocardial protection from ischemic preconditioning following chronic exposure to R(-)-N6-(2-phenylisopropyl)adenosine is related to defect at the adenosine A1 receptor.Mol Cell Biochem186:19-25 (1998).
Horton et al. Biochemical characterisation of a hibernation-specific 88 kDa protein derived from the plasma of deeply hibernating woodchucks.Adaptations to the Cold: Tenth International Hibernation Symposium, edited b

Affiliated with

Also associated with

Rating

Anti-infarction molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-infarction molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-infarction molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4159622