Anti-immunoglobulin toxin conjugates useful in the treatment of

Details Anti-immunoglobulin toxin conjugates useful in the treatment of Anti-immunoglobulin toxin conjugates useful in the treatment of

1983-05-27

1988-12-20

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

530387, A61K 39395, A61K 3944, C07K 1500, C07K 1700

Patent

active

047924470

ABSTRACT:
Highly specific antibodies directed against immunoglobulin determinants coupled to one or more toxin molecules provide antibody-toxin conjugates which are useful in selectively inhibiting the growth of target immunoglobulin generating cells. The antibody-toxin conjugate consists of an antibody specific for a selected immunoglobulin determinant including isotypic, allotypic or idiotypic variable determinants, coupled to one or more toxin molecules. Anti-idiotype toxin conjugates are provided which have specificity which distinguishes B cell tumor cells from normal B cells. Also disclosed is an antibody-toxin conjugate consisting of anti-IgD A chain. The antibody-toxin conjugate is used as a cell or tumor specific cytotoxic agent directed selectively against those cells expressing the corresponding immunoglobulin to which the antibody portion has specificity.

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