Anti-IL-20 antibody and its use in treating IL-20 associated...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S130100, C424S133100, C530S351000

Reexamination Certificate

active

07611705

ABSTRACT:
This invention features an antibody specifically binding to human IL-20 (e.g., mAb 7E and a equivalent thereof) and its use in treating an IL-20 associated inflammatory disease, such as atherosclerosis, RA, psoriasis, psoriatic arthritis, bacteria-induced gastric ulcer, and acute renal failure.

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Hsu Y.H. et al., “Function of Interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis”, Arthritis and Rheumatism, vol. 54(9), pp. 2722-2733 (Sep. 2006).
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Wei C.C. et al., “IL-20: Biological functions and clinical implications”, Journal of Biomedical Science, vol. 13(5), pp. 601-612 (May 16, 2006).
Sabat R. et al., “IL-19 and IL-20: Two novel cytokines with importance in inflammatory diseases”, Expert Opinion on Therapeutic Targets, vol. 11(5), pp. 601-612 (May 2007).
Wei C.C. et al., “Detection of IL-20 and its receptors on psoriatic skin”, Clinical Immunology, vol. 117(1), pp. 65-72 (Oct. 2005).

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