Anti-idiotypic monoclonal antibodies and compositions including

Details Anti-idiotypic monoclonal antibodies and compositions including Anti-idiotypic monoclonal antibodies and compositions including

1998-01-29

2000-05-16

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241381, 5303872, 5303877, 5303881, A61K 39395, C07K 1600

Patent

active

060633794

ABSTRACT:
An anti-idiotypic monoclonal antibody that is specific against the N-glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an immunomodulator for cancer treatment. Specifically, the anti-idiotype monoclonal antibody of the present invention is capable of inducing a predominant anti-idiotypic response in xenogeneic models. The anti-idiotypic monoclonal antibody also exerts a protective effect against malignant tumors in animals.

REFERENCES:
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