Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-02
1998-03-17
Loring, Susan A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303875, 5303913, 5303911, C07K 1642, C07K 1618
Patent
active
057288127
ABSTRACT:
Antibodies directed against idiotypes on naturally occurring human anti-animal antibodies are disclosed for use in inhibiting xenograft rejection in human patients. An effective quantity of these anti-idiotypic antibodies is injected into the actual or potential xenograft recipient in order to bind to the idiotypes expressed on anti-animal antibodies as well as subpopulations of B lymphocytes, to inhibit hyperacute rejection of transplanted animal tissues or organs by the human patient. Alternatively, anti-idiotypic antibodies are used in the form of immunoaffinity columns to deplete anti-animal antibodies from the recipient's serum. Methods of making mouse monoclonal, mouse recombinant, and human recombinant anti-idiotypic antibodies are described, as well as immunoaffinity columns containing immobilized anti-idiotypic antibodies. A method and means for assessing the expected character and severity of a patient's rejection response to transplanted animal tissues is described, as well as methods of identification, isolation and suppression of lymphocytes bearing anti-animal idiotypes.
REFERENCES:
patent: 5215904 (1993-06-01), Gould et al.
Geller, R.L. et al, Transplantation, 55:168-172, Jan. 1, 1993.
Reed., E. et al NEJM, 316:1450-1455, 1987.
Galili, U. et al, J Exp Med, 160:1519-1531, Nov. 1984.
Fischel, R. J. et al., Transplantation Proceedings, 22(3):1077-1078, 1990.
Sandrin, M. S. et al., PNAS, 90:11391-11395, Dec. 1993.
Abdou, N.J., et al., "In Virro Suppression of Serum Anti-DNA Antibody Binding to DNA by Anti-Idiotypic Antibody in Systemic Lupus Erythematosus", J. Clin. Invest., 67:1297-1304 (May, 1981).
Bach, F.H., et al., "Accomodation: A Working Paradigm for Progressing Toward Clinical Discordant Xenografting", Transplant. Proc., 23(1):205-207 (Feb., 1991).
Brodsky, F.M., et al., "Evolution of HLA Antigenic Determinants: Species Cross-reactions of Monoclonal Antibodies", Immunogenetics, 155:151-166 (1982).
Clackson, T., et al., "Making Antibody Fragments Using Phage Display Libraries", Nature, 352:624-688 I(Aug. 1991).
Cooper, D.K.C., et al., "The Pig as Potential Organ Donor for Man", Xenotransplantation, Springer-Verlag:481-500 (1991).
Cooper, D.K.C., et al., "Effects of Cyclosporine and Antibody Adsorption on Pig Cardiac Xenograft Survival in the Baboon", J. Heart Transplant, 7:238-246 (May/Jun., 1988).
Cooper, D.K.C., "Immediate Postoperative Care and Maintenance Immunosuppresive Therapy", 89-100 in Cooper, D.K.C. and Novitzky, D., eds., The Transplantation and Replacement of Thoracic Organs, (Kluwer, Dordrecht 1990).
Daugherty, B.L., et al., "Polymerase Chain Reaction Facilitates the Cloning, CDR-Grafting, and Rapid Expression of a Murine Monoclonal Antibody Directed Against the CD18 Component of Leukocyte Integrins", Nucl. Acids Res., 19:2471-2476 (1991).
Galili, U., et al., "A Unique Natural Human IgG Antibody with Anti-.alpha.-Galactosyl Specificity", J. Exp. Med., 160:1519-1531 (Nov., 1984).
Galili, U., et al., "Interaction Between Human Natural Anti-.alpha.-Galactosyl Immunoblobulin G and Bacteria of the Human Flora", Infection and Immunity, 56(7):1730-1737 (Jul., 1988).
Garver, J.J., et al., "Evidence of Similar Organization of the Chromosomes Carrying the Major Histocompatibility Complex in Man and Other Primates", Cytogenetics & Cell Genetics, 27:238-245 (1980).
Geller, R.L., et al., "Evidence that Polyreactaive Antibodies are Deposited in Rejected Discordant Xenografts", Transplantation, 55:168-172 (Jan., 1993).
Good, A.H., et al., "Identification of Carbohydrate Structures that Bind Human Antiporcine Antibodies: Implications for Discordant Xenografting in Humans", Transplant Proc., 24(2):559-652 (Apr., 1992).
Hammer, C., "Evolutionary Considerations in Xenotransplantation", Xenograft, 25:115-123 (1989).
Hammer, C., et al., "Evolutionary, Physiological, and Immunological Considerations in Defining a Suitable Donor for Man", Xenotransplantation, 429-438 (1991).
Jerne, N.K., et al., "Recurrent Idiotopes and Internal images", EMBO Journal, 1:243-247 (Feb., 1982).
Koren, E., et al., "Heterogeneity of Preformed Human Antipig Xenogeneic Antibodies", Transplant Proc., 24(2):598-601 (Apr. 1992).
Lexer, G., et al., "Hyperacute Rejection in a Discordant (Pig to Baboon) Cardiac Xenograft Model", J. Heart Transplant, 4:411-418 (1986).
McCafferty, J., et al., "Phage Antibodies: Filamentous Phage Displaying Antibody Variable Domains", Nature, 348:552-554 (Dec., 1990).
Meeker, T.C.J., et al., "A Clinical Trial of Anti-Idiotype Therapy for B Cell Malignancy", Blood, 65:1349-1355 (Jun. 1985).
Michler. R.E., et al., "Prolongation of Primate Cardiac Xenograft Survival with Cyclosporine", Transplantation, 44(5):632-636 (Nov., 1987).
Miyajima, T., et al., "Anti-Idiotypic Antibodies in a Patient with a Functioning Renal Graft", Nature, 283:306-308 (Jan., 1980).
Neubauer, R.H., et al., "Reactaivity of Monoclonal Antibodies Against Human Leucocyte Antigens with Lymphocytes of Non-Human Primate Origin", J. Immunogenetics, 8:433-442 (Dec., 1981).
Norman, D.J., et al., "Consensus Statement Regarding OKT3-Induced Cytokine-Release Syndrome and Human Antimouse Antibodies", Transplant Proc., 25(2):1:89-92 (Apr., 1993).
Oosterlaken, T.A.M., et al., "A Neutralization-Inhibition Enzyme Immunoassay for Anti-Idiotypic Antibodies that Block Monoclonal Antibodies Neutralizing Semliki Forest Virus", J. Immunol. Methods, 115:255--261 (1988).
Paul, L.C., et al., "Mechanism of Humoral Xenograft Rejection", Xenotransplantation, 47-67 (1991).
Platt, J.L., et al., "Mechanism of Tissue Injury in Hyperacute Xenograft Rejection", Xenotransplantation, 69-79 (Aug., 1991).
Platt, J.L., et al., "Immunopathology of Hyperacute Xenograft Rejection in a Swine-to-Primate Model", Transplantation, 52(2):214-220 (1991).
Polanka, E., et al., "Anti-Idiotypic Antibodies to HLA After Donor-Specific Blood Transfusion (DST)", Transplant. Proc., 21:1806-1809 (Feb., 19890.
Reed, E., et al., "Effect of Antiidiotypic Antibodies to HLA on Graft Survival in Renal-Allograft Recipients", New Engl. J. Med., 316:1450-1455 (Jun. 1987).
Reed, E., et al., "Effect of Anti-HLA and Anti-Idiotypic Antibodies on the Long-Term Survival of Heart and Kidney Allografts", Transplant. Proc., 24:2494-2495.
Rodey, J.E., et al., "Association of Antiidiotypic Antibody with Successful Second Transplant of a Kidney Sharing HLA Antigens with the Previous Hyperacutely Rejected First Kidney", Transplantation, 48:54-57 (Jul., 1989).
Sasaki, T., et al., "Selective Elimination of Anti-DNA Antibody-producing Cells by Antiidiotypic Antibody Conjugated with Neocarzinostatin", J. Clin. Invest., 77:1382-1386 (1986).
Simpson, M.A., et al., "Immunosuppression in Xenotransplantation", Xenograft, 25:273-284 (1989).
Somerville, C.A., et al., "Future Directions in Transplantation: Xenotransplantation", Kidney Int., 44(42):S112-S121 (1993).
Stark, J.H., et al., "Immunological Compatibility Between the Chacma Baboon and Man", Transplantation, 52(6):1072-1078 (Dec., 1991).
Tsujisaki, M., et al., "A Sandwich Assay to Detect and Characterize Syngeneic Anti-Idiotypic Antibodies to murine Anti-HLA and Tumor Associated Associated Antigen Monoclonal Antibodies", J. Immunol. Methods, 95:47-55 (1986).
Welsh, K.I., et al., "Human Antibodies to Pig Determinants and Their Association with Hyperacute Rejection of Xenografts", Xenotransplanation, 501-510 (1991).
Werner, R.G., et al., "Safety and Economic Aspects of Continuous Mammalian Cell Culture", Biotechnol., 22:51-68 (1992).
Ye, Y., Cooper, et al., "Experimental Xenotransplantation in Nonhuman Primates Using Distantly Related Donor Species", Xenotransplantation, 389-393 (1991).
Cooper, D.K.C., "Is Xenotransplantation a Realistic Clinical Option?," Trans. Proc. 24(5):2393-2396 (1992).
Salame, et al., "Rejet hyperaigu xenogenique: tentative de traitement a l'aide d'anticorps anti-idiotypiques," La Presse Medicale 21, n.degree. 41:1945-1946 (1992).
Cooper David K. C.
Koren Eugen
Baptist Medical Center of Oklahoma, Inc.
Loring Susan A.
Oklahoma Medical Research Foundation
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