Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2008-05-20
2008-05-20
Lucas, Z. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S004000, C435S007100
Reexamination Certificate
active
10474296
ABSTRACT:
The present invention provides methods for the diagnosis, prognosis and treatment of HCV-related disease. The method takes advantage of a novel reactive mechanism of the murine monoclonal antibody (mAb) 1F7 against human antibodies specific for different proteins of the Hepatitis C Virus (HCV) and Human immunodeficiency virus (HIV). 1F7 recognizes antibodies against HCV core protein in a majority of HCV-infected individuals and antibodies against HCV non-structural proteins 3 (NS3) and NS4 in some HCV-infected individuals. 1F7 also recognizes antibodies against the putative principle neutralizing determinant (hypervariable and conserved region 1 of the HCV E2 protein) of HCV. The antibody can be used in various methods to detect HCV related disease and formulated with physiologically acceptable carriers in various compositions to treat HCV infection.
REFERENCES:
patent: 5849583 (1998-12-01), Müller et al.
patent: 6146627 (2000-11-01), Müller et al.
patent: 6692908 (2004-02-01), Foung et al.
patent: 2002/0090607 (2002-07-01), Fields et al.
patent: 2003/0186269 (2003-10-01), Bahr et al.
patent: WO 94/14974 (1994-07-01), None
patent: WO 00/26418 (2000-11-01), None
patent: WO 01/88128 (2001-11-01), None
Wang et al., “Identification of an idiotypic peptide recognized by autoantibodies in human immunodeficiency virus-1-infected individuals,” Journal of Clinial Investigation, vol. 96 No. 2, pp. 775-780 (Aug. 1995).
Mizorogi et al., “Hepatitis C virus infection in patients with B-cell non-Hodgkin's lymphoma,” Internal Medicine, vol. 39 No. 2, pp. 112-117 (Feb. 2000).
Askonas, B. and Williamson, A., “Dominance of a Cell Clone Forming Antibody to DNP,”Nature, 238:339-341 (Aug. 1972).
Bain, Allen, “Immune Network Initiates Hepatitis C Research,”News Bites, Online!, <www.askemilyss.com/bites/bite0300/imm.htm> (Jun. 24, 2002).
Bebenek, K. et al., “Specificity and Mechanism of Error-Prone Replication by Human Immunodeficiency Virus-1 Reverse Transcriptase,”J. Biol. Chem., 264:16948-16956 (Oct. 5, 1989).
Berberian, L. et al., “Immunoglobuling Vh3 Gene Products: Natural Ligands for HIV gp120,”Science, 261:1588-1591 (Sep. 1993).
Blank, M. et al., “The Importance of the Pathogenic 16/6 Idiotype in the Induction of SLE in Naive Mice,”Scand. J. Immunol., 31:45-52 (1990).
Briles, D. and Davie, J., “Clonal Nature of the Immune Response,”J. Exp. Med., 152:151-160 (Jul. 1980).
Chen, M. et al., “Limited Humoral Immunity In Hepatitis C Virus Infection,”Gastroenterology, 116:135-43 (Jan. 1999).
Cohen, Irun, “The Cognitive Paradigm and the Immunological Homunculus,”Immunol. Today, 13:490-494 (1992).
Grant, M. et al., “Distribution of Antibodies Against Denatured Collagen in AIDS Risk Groups and Homosexual Aids Patients Suggests a Link Between Autoimmunity and the Immunopathogenesis of AIDS,”J. Immunol., 144:1241-1250 (Feb. 1990).
Grant, M. et al., “Similar Abnormalities of Idiotype and Immunoglobulin Light Chain Expression and of Cell-Mediated Cytotoxicity in HIV-Infected Humans and Simian Immunodeficiency Virus (Siv)-Infected Rhesus Macaques,”Immunol. Cell Biol., 74:38-44 (1996).
Grant, Michael, “Antibody Convergence Along a Common Idiotypic Axis in Iinmunodeficiency Virus and Hepatitis C Virus Infections,”J. Med. Virol., 66:13-21 (2002).
Kang, C. et al., “Evidence for Non-V3-Specific Neutralizing Antibodies that Interfere with gp120/CD4 Binding in Human Immunodeficiency Virus 1-Infected Humans,”Proc. Natl. Acad. Sci. USA, 88:6171-6175 (Jul. 1991).
Kennedy, R. and Dreesman, G., “Antigen Mimicry by Anti-Idiotype Antibodies that Recognize a Common Anti-Hepatitis B Surface Antigen Idiotype,”Adv. Exp. Med. Biol., 185:139-147 (1985).
Köhler, H. et al., “Deceptive Imprinting in the Immune Response Against HIV-1,”Immunol. Today, 15:475-478 (1994).
Köhler, H. et al., “Why AIDS Vaccines That Induce Humoral Immunity May Not Work,”The Immunologist, 3:32-33 (1995).
Konikoff, F. et al., “Common Lupus Anti-DNA Antibody Idiotypes in Chronic Liver Diseases,”Clin. Immunol. Immunopathol., 43:265-272 (1987).
Mendlovic, S. et al., “In Vitro T-Cell Functions Specific to an Anti-DNA Idiotype and Serological Markers in Patients with Systemic Lupus Erythematosus (SLE),”J. Clin. Immunol., 8:178-187 (1988).
Montefiori, D. et al., “Homotypic Antibody Responses to Fresh Clinical Isolates of Human Immunodeficiency Virus,”Virology, 182:635-643 (1991).
Müller, S. et al., “Stimulation of HIV-1-Neutralizing Antibodies Insimian HIV-IIIB-Infected Macaques,”Proc. Natl. Acad. Sci. USA, 95:276-281 (Jan. 1998).
Nara, P. et al., “Absence of Cytotoxic Antibody to Human Immunodeficiency Virus-Infected Cells in Humans and its Induction in Animals After Infection or Immunization with Purified Envelope Glycoprotein gp120,”Proc. Natl. Acad. Sci. USA, 84:3797-3801 (Jun. 1987).
Nara, P. et al., “Emergence of Viruses Resistant to Neutralization by V3-Specific Antibodies in Experimental Human Immunodeficiency Virus Type 1 IIIB Infection of Chimpanzees,”J. Virol., 64:3779-3791 (Aug. 1990).
Nara, P. et al., “Neutralization of HIV-1: a Paradox of Humoral Proportions,”FASEB J., 5:2437-2455 (Jul. 1991).
Ogata, N. et al., “Nucleotide Sequence and Mutation Rate of the H Strain of Hepatitis C Virus,”Proc. Natl. Acad. Sci. USA, 88:33392-3396 (Apr. 1991).
Puntoriero, G. et al., “Towards a Solution for Hepatitis C Virus Hypervariability: Mimotopes of the Hypervariable Region 1 Can Induce Antibodies Cross-Reacting with a Large Number of Viral Variants,”EMBO J., 17:3521-3533 (1998).
Schwartz, R. and Stollar, B., “Origins of Anti-DNA Autoantibodies,”J. Clin. Invest., 75:321-327 (Feb. 1985).
Shoenfeld, Y. et al., “Production of Autoantibodies by Human-Human Hybridomas,”J. Clin. Invest., 70:205-208 (Jul. 1982).
Wang, H. et al., “Human Monoclonal and Polyclonal Anti-Human Immunodeficiency Virus-1 Antibodies Share a Common Clonotypic Specificity,”Eur. J. Immunol., 22:1749-1755 (1992).
Webster, R.G., “Original Antigenic SIN in Ferrets: the Response to Sequential Infections with Influenza Viruses,”J. Immunol., 97:177-183 (1996).
Zhou, S. et al., “Monoclonal Antibodies to the Hypervariable Region 1 of Hepatitis C Virus Capture Virus and Inhibit Virus Adsorption to Susceptible Cells in Vitro,”Virology, 269:276-283 (2000).
Zhou, Y. and Whitaker, J., “An Idiotype Shared by Monoclonal Antibodies to Different Peptides of Human Myelin Basic Protein,”J. Immunol., 145:2554-2560 (Oct. 1990).
Besson, C. et al., “Lack of association between HCV infection and HIV-related lymphoma,”Br. J. Haematol., 105:568-569 (May 1999).
Grant, M. et al., “The anti-idiotypic antibody 1F7 selectively inhibits cytotoxic T cells activated in HIV-1 infection,”Immunol. Cell Biol., 78:20-27 (Feb. 2000).
Lucas Z.
Rapid Medical Diagnostic Corporation
LandOfFree
Anti-idiotypic antibody and its use in diagnosis and therapy... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-idiotypic antibody and its use in diagnosis and therapy..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-idiotypic antibody and its use in diagnosis and therapy... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3910061