Anti-idiotypic antibodies to human melanoma-associated proteogly

Details Anti-idiotypic antibodies to human melanoma-associated proteogly Anti-idiotypic antibodies to human melanoma-associated proteogly

1991-03-12

1993-12-14

Chan, Y. Christina

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303872, 5303873, 53038885, 5303897, 5303888, C07K 1528, C07K 1500, C12P 2108, C12N 518

Patent

active

052702022

ABSTRACT:
This application discloses a novel anti-idiotypic antibody, IMelpg2 and equivalents thereof, as well as, antibody fragments, peptides or antisera capable of reacting with at least one of the idiotopes of: (a) murine monoclonal antibody MEM136 and derivatives thereof; (b) a monoclonal antibody secreted by hybridomas from any species having the same immunological specificity as antibody MEM136; or (c) any polyclonal antibodies from any species having the same immunological specificity as antibody MEM136, wherein (a), (b), or (c) is capable of reacting with a specific determinant (epitope) of a MPG antigen are described, together with their preparation and use in the diagnosis, monitoring and treatment of tumors such as melanoma or other diseased cells that express the MPG epitope recognized by antibody MEM136.

REFERENCES:
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Kantor et al. Cancer Research 46:5223 (1986).
Wilson et al. Int. J. Cancer 28:293 (1981).
DeFrietag et al. May 15, 1985 EP 0141783.
Lazar et al. Molec. Cellul. Biol. 8: 1247 (1988).
Waldmann Science 252: 1657 (1991).
Burgess et al. J. Cell. Biol. 111: 2129 (1990).
Tao et al. Journal of Immunology vol. 143 1989 p. 25, 95.

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