Anti-idiotypic antibodies of vascular endothelial growth...

Details Anti-idiotypic antibodies of vascular endothelial growth... Anti-idiotypic antibodies of vascular endothelial growth...

2005-05-03

2005-05-03

Ewoldt, G. R. (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Anti-idiotypic

C424S278100, C530S387200, C530S388100

Reexamination Certificate

active

06887469

ABSTRACT:
An anti-idiotypic vascular endothelial growth factor antibody, an Fab fragment, and pharmaceutical compositions thereof, being ligands of the human KDR receptor or of the murine flk-1 receptor and not a ligand of flt are provided.

REFERENCES:
patent: 4737453 (1988-04-01), Primus
patent: 4792447 (1988-12-01), Uhr et al.
patent: 5942385 (1999-08-01), Hirth
patent: 0 502 416 (1992-09-01), None
patent: WO 9411499 (1994-05-01), None
Kieber-Emmons et al. in Intern. Rev. Immun., Köhler ed. 1:1-26, 1986.*
Plouet et al., J. Cell Biochem. “VEGF Tumoral Progression: STLM By αVEGF Idiotypic AB.” Supp. 18A, XP000602723, p. 328, AB EZ311, 1994.*
by Plouet et al., “VEGF Dependent Tumoral Progression: Stimulation by Anti VEGF Idiotypic Antibodies”,Journal of Cellular Biochemistry,Supplement 18A, 1994, p. 328.
by Terman et al., “Identification of the KDR Tyrosine Kinase as a Receptor for Vascular Endothelial Cell Growth Factor”,Biochemical and Biophysical Research Communications,vol. 187, No. 3, 1992, pp. 1579-1586.
by Millauer et al., “High Affinity VEGF Binding and Developmental Expression Suggest Flk-1 as a Major Regulator of Vasculogenesis and Angiogenesis”,Cell, vol. 72, 1993, pp. 835-846.
by Millauer et al., “Glioblastoma Growth Inhibited in vivo by a Dominant-Negative Flk-1 Mutant”,Nature, vol. 367, 1994, pp. 576-579.
by Kim et al., “Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis Suppresses Tumour Growth in vivo”,Nature, vol. 362, 1993, pp. 841-844.
by Chagnaud et al., “Curative Effects on Rat Sarcomas Obtained After a Treatment Combining Two Monoclonal Antibodies”,Anti-Cancer Drugs,vol. 5, 1994, pp. 361-366.

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