Anti-hypertensive compositions of benzimidazole derivatives

Details Anti-hypertensive compositions of benzimidazole derivatives Anti-hypertensive compositions of benzimidazole derivatives

1974-10-02

1976-01-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31415

Patent

active

039353141

ABSTRACT:
Antihypertensive pharmaceutical compositions comprising a compound of the formula (II) ##SPC1##
or pharmaceutically acceptable salts or solvates thereof wherein R.sub.1 is nitrile or amidino; R.sub.2 is hydrogen or lower hydrocarbon; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are each selected from hydrogen, halogen, nitro, trifluoromethyl, lower alkyl, lower acyl, hydroxyl, lower etherified hydroxyl or lower acylated hydroxyl; together with a pharmaceutically acceptable carrier. The compounds of formula (II) are also useful as intermediates in the synthesis of the corresponding 2-aminoimidazoline compounds.

REFERENCES:
patent: 3738994 (1973-06-01), Fisher
patent: 3749734 (1973-07-01), Hannah et al.
patent: 3749789 (1973-07-01), Fisher
patent: 3755314 (1973-08-01), Fauran et al.
patent: 3760081 (1973-09-01), Skaletecky

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