Anti-hypertensive 9-aminomethyl-benzo[f]quinoline-3,10-dione der

Details Anti-hypertensive 9-aminomethyl-benzo[f]quinoline-3,10-dione der Anti-hypertensive 9-aminomethyl-benzo[f]quinoline-3,10-dione der

1983-11-10

1985-09-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514290, 544126, 544361, 546101, A61K 3147, G07D22110

Patent

active

045433542

ABSTRACT:
Benzo[f]quinoline derivatives which are useful as antihypertensive agents and are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen, lower alkyl, hydroxy-lower-alkyl or lower-alkoxy-lower-alkyl, R.sup.3 and R.sup.4 are the same or different and each is hydrogen, lower alkyl, halogen, lower alkoxy, benzyloxy or hydroxy, R.sup.5 and R.sup.6 are the same or different and each is hydrogen, straight or branched alkyl, aralkyl or cycloalkyl, or R.sup.5 and R.sup.6 together with the adjacent nitrogen atom form a heterocycle, and the dotted line in the ring is an optional bond between 1- and 2-positions, and pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 3043842 (1962-07-01), Craig
patent: 4341786 (1982-07-01), DeMarinis et al.
Bardou, et al., Chemical Abstracts, vol. 67, 73,550x (1967).
Miana, et al., Chemical Abstracts, vol. 70, 77405p (1969).
Patel, et al., Chemical Abstracts, vol. 80, 14608t (1974).
Houben-Weil, Methoden der Organische Chemie, vol. XI/1, Stickstoff-verbindungen II, Amine, Georg Thieme Verlag, Stuttgart (1957), pp. 248-267.
McOmie, Protective Groups in Organic Chemistry, Plenum Press, New York (1973), pp. 62-63.

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