Anti-human tenascin monoclonal antibody

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C530S387100, C530S391100, C530S387700, C435S810000, C435S070200

Reexamination Certificate

active

07989171

ABSTRACT:
An anti-human tenascin monoclonal antibody is described, whose light and heavy chain variable region sequences are SEQ ID 1 and SEQ ID 2, respectively, its proteolytic fragments capable of binding to an antigenic epitope within the region A(1-4)-D of human tenascin, its recombinant derivatives, its conjugates and its similar functional analogues capable of binding to an antigenic epitope within the A(1-4)-D region of human tenascin.

REFERENCES:
patent: 6335014 (2002-01-01), Kusakabe
patent: 7390828 (2008-06-01), Paganelli et al.
patent: 7425317 (2008-09-01), De Santis et al.
patent: 2002-234900 (2002-08-01), None
patent: 02/066075 (2002-08-01), None
patent: 03/072608 (2003-09-01), None
patent: 03/075960 (2003-09-01), None
De Santis et al. Additivity of two anti-tenascin monoclonal antibodies for pre-targeted antibody guided radioimmunotherapy (PAGRIT). Cancer Biotherapy & Radiopharmaceuticals. Aug. 2004, 19(4): 512-541. , Abstract #26.
International Search Report of PCT/IT2005/000078, mailed Oct. 26, 2005.
Siri et al., “Human Tenascin: Primary Structure, Pre-MRNA Splicing Patterns and Localization of the Epitopes Recognized by Two Monoclonal Antibodies”, Nucleic Acids Research, vol. 19, No. 5, 1991, pp. 525-531, XP000919423.
Balza et al., “Production and Characterization of monoclonal antibodies specific for different epitopes of human tenascin”, FEBS Letters, vol. 332, No. 1-2, 1993, pp. 39-43, XP002349140.
Paganelli et al., “Antibody-Guided Three-Step Therapy for High Grade Glioma With Yttrium-90 Biotin”, European Journal of Nuclear Medicine, vol. 26, No. 4, Apr. 1999, pp. 348-357, XP008019281.

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