Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-04-06
1998-11-10
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 794, 435 23, 435 7021, 4351722, 43524027, 436506, 436524, 436528, 436531, 436534, 436538, 436548, 436512, 53038826, 935100, 935104, 935106, 935110, G01N 33573, G01N 33543, G01N 33564
Patent
active
058342125
ABSTRACT:
Anti-human stromelysin monoclonal antibodies reactive with latent and active forms of stromelysin without discrimination between the two, each being immunoreactive with only one of the antigenic determinants of human stromelysin, are provided. The use of a combination of two such monoclonal antibodies which specifically react with different antigenic determinants of human stromelysin renders it possible to accurately determine the amount of human stromelysin in human body fluids, and thus to carry out the diagnosis of rheumatoid arthritis.
There are thus provided said monoclonal antibodies per se, a sandwich enzyme immunoassay for the determination of the amount of human stromelysin in human body fluid samples using a combination of two such monoclonal antibodies, and a method for the diagnosis of rheumatoid arthritis using said immunoassay.
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Hayakawa Taro
Iwata Kazushi
Kodama Shuji
Korin Yumi
Okada Yasunori
Grun James L.
Hutzell Paula K.
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