Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-12-27
2010-11-09
Haq, Shafiqul (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007400, C435S007920, C435S007930, C435S007940, C435S007950, C435S013000, C435S070210, C435S452000, C435S331000, C435S337000, C436S518000, C436S548000, C436S069000, C530S388250, C530S391100
Reexamination Certificate
active
07829294
ABSTRACT:
The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.
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Ebinuma Hiroyuki
Matsuo Masanao
Miyazaki Osamu
Suzuki Akiko
Tanaka Kyoko
Daiichi Pure Chemicals Co. Ltd.
Grun James L
Haq Shafiqul
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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